Long-term gastrointestinal tolerance of NUTRIOSE FB in healthy men
- PMID: 16482066
- DOI: 10.1038/sj.ejcn.1602418
Long-term gastrointestinal tolerance of NUTRIOSE FB in healthy men
Abstract
Objective: To determine the gastrointestinal (GI) tolerance of NUTRIOSE FB in men.
Design: A randomized, placebo-controlled, parallel, double-blind study.
Setting: The metabolic ward of TNO Quality of Life.
Subjects: Forty-eight subjects started the study: 16 men participated in one of the three treatments. SUBJECTS consumed either 22.5 g of pure maltodextrin (Glucidex 6), or 30 or 45 g of the dextrin NUTRIOSE FB daily for 4-5 weeks. Forty-three subjects completed the study (age: 34.7 +/- 8.2 years; BMI 24.9 +/- 3.3 kg m2).
Measurements: Tolerance of NUTRIOSE FB was examined with a GI complaints questionnaire; effectiveness on colonic flora was examined by faecal analysis; fermentation by breath hydrogen excretion measurement. Furthermore, the effect on body weight (BW), energy intake and blood parameters were examined in the study.
Results: Both doses of NUTRIOSE FB were very well tolerated and GI complaints hardly differed from the placebo treatment. No diarrhoea was reported due to NUTRIOSE FB supplementation. In the course of the study, some habituation and adaptation of GI symptoms were found. Fermentation and faecal characteristics (pH and enzyme activity) were significantly positively affected with NUTRIOSE FB treatment. Body weight in both NUTRIOSE FB groups remained stable over time, although the placebo-treated group showed a small increase in BW (Deltaday35-1 0.8 +/- 1.0 kg) (P = 0.07). However, total food intake and macronutrient composition of the diet remained the same throughout the study. No significant differences were found between the three treatment groups in hunger and satiety scores and food preferences.
Conclusions: Long-term supplementation of 30 or 45 g of the dextrin NUTRIOSE FB per day was well tolerated, and may act as a pre-biotic supplement.
Sponsorship: TNO Quality of Life was assigned by Roquette Frères to perform the study.
Similar articles
-
Short-term digestive tolerance of different doses of NUTRIOSE FB, a food dextrin, in adult men.Eur J Clin Nutr. 2004 Jul;58(7):1046-55. doi: 10.1038/sj.ejcn.1601930. Eur J Clin Nutr. 2004. PMID: 15220947 Clinical Trial.
-
Dietary supplementation of different doses of NUTRIOSE FB, a fermentable dextrin, alters the activity of faecal enzymes in healthy men.Eur J Nutr. 2005 Oct;44(7):445-51. doi: 10.1007/s00394-005-0552-0. Epub 2005 Feb 9. Eur J Nutr. 2005. PMID: 15696402 Clinical Trial.
-
The soluble fiber NUTRIOSE induces a dose-dependent beneficial impact on satiety over time in humans.Nutr Res. 2011 Sep;31(9):665-72. doi: 10.1016/j.nutres.2011.09.004. Nutr Res. 2011. PMID: 22024490 Clinical Trial.
-
Safety profile of a food dextrin: acute oral, 90-day rat feeding and mutagenicity studies.Food Chem Toxicol. 2008 Oct;46(10):3254-61. doi: 10.1016/j.fct.2008.06.092. Epub 2008 Jul 25. Food Chem Toxicol. 2008. PMID: 18701086
-
NUTRIOSE dietary fiber supplementation improves insulin resistance and determinants of metabolic syndrome in overweight men: a double-blind, randomized, placebo-controlled study.Appl Physiol Nutr Metab. 2010 Dec;35(6):773-82. doi: 10.1139/H10-074. Appl Physiol Nutr Metab. 2010. PMID: 21164548 Clinical Trial.
Cited by
-
Effects of Soluble Dietary Fibre on Exercise Performance and Perception of Fatigue in Young Basketball Players.Food Technol Biotechnol. 2023 Sep;61(3):389-401. doi: 10.17113/ftb.61.03.23.8124. Food Technol Biotechnol. 2023. PMID: 38022878 Free PMC article.
-
Effect of Resistant Dextrin on Intestinal Gas Homeostasis and Microbiota.Nutrients. 2022 Nov 2;14(21):4611. doi: 10.3390/nu14214611. Nutrients. 2022. PMID: 36364873 Free PMC article.
-
Resistant dextrin protects against pathological bone loss in ovariectomized rats and inhibits RANKL-induced osteoclastogenesis.Histol Histopathol. 2022 Nov;37(11):1127-1141. doi: 10.14670/HH-18-492. Epub 2022 Jul 8. Histol Histopathol. 2022. PMID: 35801271
-
Effects of Resistant Dextrin from Potato Starch on the Growth Dynamics of Selected Co-Cultured Strains of Gastrointestinal Bacteria and the Activity of Fecal Enzymes.Nutrients. 2022 May 22;14(10):2158. doi: 10.3390/nu14102158. Nutrients. 2022. PMID: 35631299 Free PMC article.
-
Diet Supplementation with NUTRIOSE, a Resistant Dextrin, Increases the Abundance of Parabacteroides distasonis in the Human Gut.Mol Nutr Food Res. 2022 Jun;66(11):e2101091. doi: 10.1002/mnfr.202101091. Epub 2022 Apr 4. Mol Nutr Food Res. 2022. PMID: 35312171 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical