Sex differences in antidepressant response in recent antidepressant clinical trials
- PMID: 16012273
- DOI: 10.1097/01.jcp.0000168879.03169.ce
Sex differences in antidepressant response in recent antidepressant clinical trials
Abstract
Some previous reports suggest that women respond differently than men to antidepressant treatment. Much of this literature compares men and women's response to tricyclics to that of newer antidepressants (SSRIs, SNRI), or only examines one particular antidepressant. This study compares men and women's responses to 6 newer antidepressants. A total of 15 randomized, placebo-controlled trials that included 323 depressed patients were examined for sex differences in antidepressant treatment response. Women had a significantly greater response than men to SSRI antidepressants. A similar trend was seen for those assigned to an SNRI antidepressant, although not to the same extent as with SSRI antidepressants. Although these gender differences in treatment response are not large enough to suggest that gender should guide the clinical use of SSRI and SNRI antidepressants, the results do have implications for the design and interpretation of antidepressant clinical trials. These findings also raise the possibility that antidepressants may work somewhat differently in men and women.
Similar articles
-
BMI, sex, and antidepressant response.J Affect Disord. 2007 Apr;99(1-3):101-6. doi: 10.1016/j.jad.2006.08.027. Epub 2006 Sep 27. J Affect Disord. 2007. PMID: 17010444
-
[Selective serotonin reuptake inhibitors and newer antidepressive substances in child and adolescent psychiatry].Z Kinder Jugendpsychiatr Psychother. 2002 Aug;30(3):173-83. doi: 10.1024//1422-4917.30.3.173. Z Kinder Jugendpsychiatr Psychother. 2002. PMID: 12227220 Review. German.
-
Effects of nefazodone on body weight: a pooled analysis of selective serotonin reuptake inhibitor- and imipramine-controlled trials.J Clin Psychiatry. 2001 Apr;62(4):256-60. J Clin Psychiatry. 2001. PMID: 11379839
-
Antidepressant class, age, and the risk of deliberate self-harm: a propensity score matched cohort study of SSRI and SNRI users in the USA.CNS Drugs. 2014 Jan;28(1):79-88. doi: 10.1007/s40263-013-0120-8. CNS Drugs. 2014. PMID: 24146116 Free PMC article.
-
Are antidepressant drugs that combine serotonergic and noradrenergic mechanisms of action more effective than the selective serotonin reuptake inhibitors in treating major depressive disorder? A meta-analysis of studies of newer agents.Biol Psychiatry. 2007 Dec 1;62(11):1217-27. doi: 10.1016/j.biopsych.2007.03.027. Epub 2007 Jun 22. Biol Psychiatry. 2007. PMID: 17588546 Review.
Cited by
-
Pharmacological characterization of sex differences in the effects of dopaminergic drugs on effort-based decision making in rats.Psychopharmacology (Berl). 2024 Jun 6. doi: 10.1007/s00213-024-06615-8. Online ahead of print. Psychopharmacology (Berl). 2024. PMID: 38842701
-
Functional brain responses to emotional faces after three to five weeks of intake of escitalopram in healthy individuals: a double-blind, placebo-controlled randomised study.Sci Rep. 2024 Feb 7;14(1):3149. doi: 10.1038/s41598-024-51448-2. Sci Rep. 2024. PMID: 38326352 Free PMC article. Clinical Trial.
-
Depression in Women: Potential Biological and Sociocultural Factors Driving the Sex Effect.Neuropsychobiology. 2024;83(1):2-16. doi: 10.1159/000531588. Epub 2024 Jan 25. Neuropsychobiology. 2024. PMID: 38272005 Free PMC article. Review.
-
Impact of sex on antidepressant discontinuation in groups of similar cytochrome P450 phenotypes.Ment Health Clin. 2023 Dec 1;13(6):303-310. doi: 10.9740/mhc.2023.12.303. eCollection 2023 Dec. Ment Health Clin. 2023. PMID: 38058598 Free PMC article.
-
Transcriptional signatures of early-life stress and antidepressant treatment efficacy.Proc Natl Acad Sci U S A. 2023 Dec 5;120(49):e2305776120. doi: 10.1073/pnas.2305776120. Epub 2023 Nov 27. Proc Natl Acad Sci U S A. 2023. PMID: 38011563 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources