Immunosurveillance by gammadelta T cells: focus on the murine system
- PMID: 15976492
- DOI: 10.1159/000086658
Immunosurveillance by gammadelta T cells: focus on the murine system
Abstract
Physiologic immune responses are an integration of the activities of several lymphoid cell types that include qualitatively distinct T cell subsets. The contributions that specific T cell subsets make during infection, inflammation, and carcinogenesis is becoming increasingly clear from a variety of mouse models and, importantly, their backcrossing onto different genetic backgrounds. This review considers what we have learned in the mouse about the crucial roles played by gammadelta T cells. We consider how the cells' associations with specific tissues have revealed that T cell responses are regulated locally as well as systemically, and we discuss the implications of this for understanding and enhancing immune surveillance in the clinical setting.
Similar articles
-
Understanding the complexity of γδ T-cell subsets in mouse and human.Immunology. 2012 Jul;136(3):283-90. doi: 10.1111/j.1365-2567.2012.03582.x. Immunology. 2012. PMID: 22385416 Free PMC article. Review.
-
Lysis of a broad range of epithelial tumour cells by human gamma delta T cells: involvement of NKG2D ligands and T-cell receptor- versus NKG2D-dependent recognition.Scand J Immunol. 2007 Aug-Sep;66(2-3):320-8. doi: 10.1111/j.1365-3083.2007.01963.x. Scand J Immunol. 2007. PMID: 17635809
-
Gamma delta T cells provide an early source of interferon gamma in tumor immunity.J Exp Med. 2003 Aug 4;198(3):433-42. doi: 10.1084/jem.20030584. J Exp Med. 2003. PMID: 12900519 Free PMC article.
-
Human intestinal Vdelta1+ lymphocytes recognize tumor cells of epithelial origin.J Exp Med. 1996 Apr 1;183(4):1681-96. doi: 10.1084/jem.183.4.1681. J Exp Med. 1996. PMID: 8666926 Free PMC article.
-
γδ T Cell Update: Adaptate Orchestrators of Immune Surveillance.J Immunol. 2019 Jul 15;203(2):311-320. doi: 10.4049/jimmunol.1800934. J Immunol. 2019. PMID: 31285310 Review.
Cited by
-
CD8⁺ T Cell-Independent Immune-Mediated Mechanisms of Anti-Tumor Activity.Crit Rev Immunol. 2015;35(2):153-72. doi: 10.1615/critrevimmunol.2015013607. Crit Rev Immunol. 2015. PMID: 26351148 Free PMC article. Review.
-
γδ T Lymphocytes Coordinate Eosinophil Influx during Allergic Responses.Front Pharmacol. 2012 Dec 3;3:200. doi: 10.3389/fphar.2012.00200. eCollection 2012. Front Pharmacol. 2012. PMID: 23316161 Free PMC article.
-
Good news-bad news: the Yin and Yang of immune privilege in the eye.Front Immunol. 2012 Nov 27;3:338. doi: 10.3389/fimmu.2012.00338. eCollection 2012. Front Immunol. 2012. PMID: 23230433 Free PMC article.
-
Distribution and development of the postnatal murine Vδ1 T-cell receptor repertoire.Immunology. 2010 Oct;131(2):192-201. doi: 10.1111/j.1365-2567.2010.03290.x. Immunology. 2010. PMID: 20465568 Free PMC article.
-
Adoptively transferred ex vivo expanded gammadelta-T cells mediate in vivo antitumor activity in preclinical mouse models of breast cancer.Breast Cancer Res Treat. 2010 Jul;122(1):135-44. doi: 10.1007/s10549-009-0527-6. Epub 2009 Sep 18. Breast Cancer Res Treat. 2010. PMID: 19763820 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
