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Comparative Study
. 2004 Dec 22;15(18):2701-5.

Neural correlates of speech anticipatory anxiety in generalized social phobia

Jeffrey P Lorberbaum  1 , Samet Kose, Michael R Johnson, George W Arana, Lindsay K Sullivan, Mark B Hamner, James C Ballenger, R Bruce Lydiard, Peter S Brodrick, Daryl E Bohning, Mark S George
Affiliations
  • PMID: 15597038
Comparative Study

Neural correlates of speech anticipatory anxiety in generalized social phobia

Jeffrey P Lorberbaum et al. Neuroreport. .

Abstract

Patients with generalized social phobia fear embarrassment in most social situations. Little is known about its functional neuroanatomy. We studied BOLD-fMRI brain activity while generalized social phobics and healthy controls anticipated making public speeches. With anticipation minus rest, 8 phobics compared to 6 controls showed greater subcortical, limbic, and lateral paralimbic activity (pons, striatum, amygdala/uncus/anterior parahippocampus, insula, temporal pole)--regions important in automatic emotional processing--and less cortical activity (dorsal anterior cingulate/prefrontal cortex)--regions important in cognitive processing. Phobics may become so anxious, they cannot think clearly or vice versa.

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