Anxiety is functionally segregated within the septo-hippocampal system
- PMID: 14972654
- DOI: 10.1016/j.brainres.2003.10.065
Anxiety is functionally segregated within the septo-hippocampal system
Abstract
Previous lesion studies have suggested that the septal-hippocampal system is involved in fear and anxiety. In this study we examined the effects on anxiety of temporary neuronal inhibition of various aspects of the septo-hippocampal system in rats. Infusions of tetrodotoxin (TTX) were used to induce reversible lesions in the fimbria fornix, medial septum, dorsal hippocampus, and ventral hippocampus. To assess anxiety we used the elevated plus-maze and the shock-probe burying tests. A reduction in anxiety in the elevated plus-maze is indicated by increased open arm exploration, whereas a reduction in anxiety in the shock-probe burying test is indicated by decreased burying behavior or increased contacts with the shock-probe. The results suggested that inhibition of the septal-hippocampal system induced site-specific anxiolytic effects that vary in nature. Tetrodotoxin lesions of the fimbria fornix increased both open arm exploration and the number of shocks taken by the rats, while having no effect on burying behavior. Both septal and ventral hippocampal lesions increased open arm exploration and decreased burying behavior, but had no effect on the number of probe shocks. Finally, TTX lesions of the dorsal hippocampus increased the number of shocks taken by the rats, but did not affect open arm activity or burying behavior. Neuroanatomical studies indicated that the effect on the number of shocks induced by dorsal hippocampal TTX lesions was not likely mediated by the amygdala. Collectively, the data suggest that the control of specific anxiety reactions is functionally segregated within different aspects of the septo-hippocampal system.
Similar articles
-
Lateral and medial septal lesions reduce anxiety in the plus-maze and probe-burying tests.Physiol Behav. 1996 Sep;60(3):845-53. doi: 10.1016/0031-9384(96)00138-2. Physiol Behav. 1996. PMID: 8873261
-
Septal GABAergic and hippocampal cholinergic systems modulate anxiety in the plus-maze and shock-probe tests.Pharmacol Biochem Behav. 2001 Jul-Aug;69(3-4):391-9. doi: 10.1016/s0091-3057(01)00541-x. Pharmacol Biochem Behav. 2001. PMID: 11509196
-
The anxiolytic effects of intra-hippocampal midazolam are antagonized by intra-septal L-glutamate.Brain Res. 2001 Jan 5;888(1):163-166. doi: 10.1016/s0006-8993(00)03046-8. Brain Res. 2001. PMID: 11146063
-
Correlations between radial-maze learning and structural variations of septum and hippocampus in rodents.Behav Brain Res. 1995 Feb;67(1):29-41. doi: 10.1016/0166-4328(95)91998-3. Behav Brain Res. 1995. PMID: 7748498 Review.
-
Regional dissociations within the hippocampus--memory and anxiety.Neurosci Biobehav Rev. 2004 May;28(3):273-83. doi: 10.1016/j.neubiorev.2004.03.004. Neurosci Biobehav Rev. 2004. PMID: 15225971 Review.
Cited by
-
The chemokine XCL1 functions as a pregnancy hormone to program offspring innate anxiety.Brain Behav Immun. 2024 May;118:178-189. doi: 10.1016/j.bbi.2024.02.032. Epub 2024 Feb 29. Brain Behav Immun. 2024. PMID: 38428650
-
Monoamine Oxidase: A Potential Link in Papez Circuit to Generalized Anxiety Disorders.CNS Neurol Disord Drug Targets. 2024;23(5):638-655. doi: 10.2174/1871527322666230412105711. CNS Neurol Disord Drug Targets. 2024. PMID: 37055898 Review.
-
Lateral septum-lateral hypothalamus circuit dysfunction in comorbid pain and anxiety.Mol Psychiatry. 2023 Mar;28(3):1090-1100. doi: 10.1038/s41380-022-01922-y. Epub 2023 Jan 16. Mol Psychiatry. 2023. PMID: 36642737 Free PMC article.
-
Hippocampal acetylcholine modulates stress-related behaviors independent of specific cholinergic inputs.Mol Psychiatry. 2022 Mar;27(3):1829-1838. doi: 10.1038/s41380-021-01404-7. Epub 2022 Jan 8. Mol Psychiatry. 2022. PMID: 34997190 Free PMC article.
-
Irisin Acts via the PGC-1α and BDNF Pathway to Improve Depression-like Behavior.Clin Nutr Res. 2021 Oct 20;10(4):292-302. doi: 10.7762/cnr.2021.10.4.292. eCollection 2021 Oct. Clin Nutr Res. 2021. PMID: 34796134 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical