Collapsin response mediator proteins (CRMPs): involvement in nervous system development and adult neurodegenerative disorders
- PMID: 14514985
- DOI: 10.1385/MN:28:1:51
Collapsin response mediator proteins (CRMPs): involvement in nervous system development and adult neurodegenerative disorders
Abstract
The members of the collapsin response mediator protein (CRMP) family-five cytosolic phosphoproteins -are highly expressed throughout brain development. The first member to be cloned, CRMP2, was identified as an intracellular messenger required for the growth cone-collapse induced by semaphorin 3A (Sema3A). A rapidly expanding body of study indicates that the functions of CRMPs are not solely limited to the signaling transduction of the Sema3A guidance cue. They are probably involved in multiple cellular and molecular events involved in apoptosis/proliferation, cell migration, and differentiation. In the adult brain, the expression of CRMPs is dramatically downregulated. However, they remain expressed in structures that retain their capacity for differentiation and plasticity and also in a subpopulation of oligodendrocytes (CRMP2 and CRMP5). Moreover, the expression of CRMPs is altered in neurodegenerative diseases, and these proteins may be of key importance in the physiopathology of the adult nervous system.
Similar articles
-
Isolation and expression pattern of human Unc-33-like phosphoprotein 6/collapsin response mediator protein 5 (Ulip6/CRMP5): coexistence with Ulip2/CRMP2 in Sema3a- sensitive oligodendrocytes.J Neurosci. 2001 Sep 15;21(18):7203-14. doi: 10.1523/JNEUROSCI.21-18-07203.2001. J Neurosci. 2001. PMID: 11549731 Free PMC article.
-
Age-dependent expression of collapsin response mediator proteins (CRMPs) in cat visual cortex.Eur J Neurosci. 2004 Apr;19(8):2345-51. doi: 10.1111/j.0953-816X.2004.03330.x. Eur J Neurosci. 2004. PMID: 15090061
-
Molecular basis of semaphorin-mediated axon guidance.J Neurobiol. 2000 Aug;44(2):219-29. doi: 10.1002/1097-4695(200008)44:2<219::aid-neu11>3.0.co;2-w. J Neurobiol. 2000. PMID: 10934324 Review.
-
The CRMP family of proteins and their role in Sema3A signaling.Adv Exp Med Biol. 2007;600:1-11. doi: 10.1007/978-0-387-70956-7_1. Adv Exp Med Biol. 2007. PMID: 17607942 Free PMC article. Review.
-
Involvement of collapsin response mediator proteins in the neurite extension induced by neurotrophins in dorsal root ganglion neurons.Mol Cell Neurosci. 2004 Mar;25(3):433-43. doi: 10.1016/j.mcn.2003.11.006. Mol Cell Neurosci. 2004. PMID: 15033171
Cited by
-
Inhibition of ERK1/2 or CRMP2 Disrupts Alcohol Memory Reconsolidation and Prevents Relapse in Rats.Int J Mol Sci. 2024 May 17;25(10):5478. doi: 10.3390/ijms25105478. Int J Mol Sci. 2024. PMID: 38791516 Free PMC article.
-
Quercetin attenuated ischemic stroke induced neurodegeneration by modulating glutamatergic and synaptic signaling pathways.Heliyon. 2024 Mar 20;10(7):e28016. doi: 10.1016/j.heliyon.2024.e28016. eCollection 2024 Apr 15. Heliyon. 2024. PMID: 38571617 Free PMC article.
-
Nicotine Exposure in a Phencyclidine-Induced Mice Model of Schizophrenia: Sex-Selective Medial Prefrontal Cortex Protein Markers of the Combined Insults in Adolescent Mice.Int J Mol Sci. 2023 Sep 27;24(19):14634. doi: 10.3390/ijms241914634. Int J Mol Sci. 2023. PMID: 37834084 Free PMC article.
-
Collapsin response mediator protein 5-associated optic neuropathy: clinical characteristics, radiologic clues, and outcomes.Front Neurol. 2023 Jun 28;14:1163615. doi: 10.3389/fneur.2023.1163615. eCollection 2023. Front Neurol. 2023. PMID: 37448746 Free PMC article.
-
CRMP2 Participates in Regulating Mitochondrial Morphology and Motility in Alzheimer's Disease.Cells. 2023 Apr 29;12(9):1287. doi: 10.3390/cells12091287. Cells. 2023. PMID: 37174687 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous