Linearized reference tissue parametric imaging methods: application to [11C]DASB positron emission tomography studies of the serotonin transporter in human brain
- PMID: 12973026
- DOI: 10.1097/01.WCB.0000085441.37552.CA
Linearized reference tissue parametric imaging methods: application to [11C]DASB positron emission tomography studies of the serotonin transporter in human brain
Abstract
The authors developed and applied two new linearized reference tissue models for parametric images of binding potential (BP) and relative delivery (R1) for [11C]DASB positron emission tomography imaging of serotonin transporters in human brain. The original multilinear reference tissue model (MRTM(O)) was modified (MRTM) and used to estimate a clearance rate (k'2) from the cerebellum (reference). Then, the number of parameters was reduced from three (MRTM) to two (MRTM2) by fixing k'2. The resulting BP and R1 estimates were compared with the corresponding nonlinear reference tissue models, SRTM and SRTM2, and one-tissue kinetic analysis (1TKA), for simulated and actual [11C]DASB data. MRTM gave k'2 estimates with little bias (<1%) and small variability (<6%). MRTM2 was effectively identical to SRTM2 and 1TKA, reducing BP bias markedly over MRTM(O) from 12-70% to 1-4% at the expense of somewhat increased variability. MRTM2 substantially reduced BP variability by a factor of two or three over MRTM or SRTM. MRTM2, SRTM2, and 1TKA had R1 bias <0.3% and variability at least a factor of two lower than MRTM or SRTM. MRTM2 allowed rapid generation of parametric images with the noise reductions consistent with the simulations. Rapid parametric imaging by MRTM2 should be a useful method for human [11C]DASB positron emission tomography studies.
Similar articles
-
PET imaging of serotonin transporters with [11C]DASB: test-retest reproducibility using a multilinear reference tissue parametric imaging method.J Nucl Med. 2006 Feb;47(2):208-14. J Nucl Med. 2006. PMID: 16455625 Clinical Trial.
-
Noise reduction in the simplified reference tissue model for neuroreceptor functional imaging.J Cereb Blood Flow Metab. 2002 Dec;22(12):1440-52. doi: 10.1097/01.WCB.0000033967.83623.34. J Cereb Blood Flow Metab. 2002. PMID: 12468889
-
Positron emission tomography quantification of [(11)C]-DASB binding to the human serotonin transporter: modeling strategies.J Cereb Blood Flow Metab. 2001 Nov;21(11):1342-53. doi: 10.1097/00004647-200111000-00010. J Cereb Blood Flow Metab. 2001. PMID: 11702049 Clinical Trial.
-
Relationships between radiotracer properties and image quality in molecular imaging of the brain with positron emission tomography.Mol Imaging Biol. 2003 Nov-Dec;5(6):363-75. doi: 10.1016/j.mibio.2003.09.009. Mol Imaging Biol. 2003. PMID: 14667491 Review.
-
Positron emission tomography: imaging and quantification of neurotransporter availability.Methods. 2002 Jul;27(3):287-99. doi: 10.1016/s1046-2023(02)00085-3. Methods. 2002. PMID: 12183117 Review.
Cited by
-
The utility of PET imaging in depression.Front Psychiatry. 2024 Apr 22;15:1322118. doi: 10.3389/fpsyt.2024.1322118. eCollection 2024. Front Psychiatry. 2024. PMID: 38711875 Free PMC article. Review.
-
Alterations in adolescent brain serotonin (5HT)1A, 5HT2A, and dopamine (D)2 receptor systems in a nonhuman primate model of early life adversity.Neuropsychopharmacology. 2024 Jul;49(8):1227-1235. doi: 10.1038/s41386-023-01784-0. Epub 2024 Apr 26. Neuropsychopharmacology. 2024. PMID: 38671147
-
Reduction in Constitutively Activated Auditory Brainstem Microglia in Aging and Alzheimer's Disease.J Alzheimers Dis. 2024;99(1):307-319. doi: 10.3233/JAD-231312. J Alzheimers Dis. 2024. PMID: 38669537 Free PMC article.
-
Multimodal brain age prediction using machine learning: combining structural MRI and 5-HT2AR PET-derived features.Geroscience. 2024 Apr 26. doi: 10.1007/s11357-024-01148-6. Online ahead of print. Geroscience. 2024. PMID: 38668887
-
Does seasonal variation affect the neuroimmune system? A retrospective [11C]PBR28 PET study in healthy individuals.Neurosci Lett. 2024 Apr 1;828:137766. doi: 10.1016/j.neulet.2024.137766. Epub 2024 Apr 5. Neurosci Lett. 2024. PMID: 38583505
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical