Effects of alcohol detoxification on dopamine D2 receptors in alcoholics: a preliminary study
- PMID: 12477600
- DOI: 10.1016/s0925-4927(02)00087-2
Effects of alcohol detoxification on dopamine D2 receptors in alcoholics: a preliminary study
Abstract
Imaging studies in patients with Type II alcohol dependence have revealed significant reductions in dopamine (DA) D2 receptor availability. Here we assessed the effects of alcohol detoxification in DA D2 receptors in alcoholic subjects. We evaluated 14 patients with Type II alcohol dependence tested within 6 weeks of detoxification and then re-tested 1-4 months later while alcohol free. The comparison group comprised 11 healthy controls. PET was used with [11C]raclopride to measure DA D2 receptors. Eight alcoholics and all control subjects were tested with a CTI 931 PET scanner and six alcoholics with a Siemens HR+ PET scanner. Data were analyzed separately for the studies done in the different scanners. Comparisons between early and late alcohol detoxification showed no significant changes in DA D2 receptor availability (B(max)/K(d)) for the studies done with the CTI and the HR+ scanners. Comparison with controls showed lower DA D2 receptor levels in caudate and putamen in alcoholics tested during early detoxification and in caudate during late detoxification. These studies replicate previous findings of lower striatal DA D2 receptors in alcoholics than in controls and absence of significant recovery during alcohol detoxification. These findings suggest that low DA D2 receptor availability in alcoholics is not due to alcohol withdrawal and may reflect a predisposing factor.
Similar articles
-
Striatal D2 dopamine receptor binding characteristics in vivo in patients with alcohol dependence.Psychopharmacology (Berl). 1994 Nov;116(3):285-90. doi: 10.1007/BF02245330. Psychopharmacology (Berl). 1994. PMID: 7892418 Clinical Trial.
-
Relation of dopamine receptor 2 binding to pain perception in female fibromyalgia patients with and without depression--A [¹¹C] raclopride PET-study.Eur Neuropsychopharmacol. 2016 Feb;26(2):320-330. doi: 10.1016/j.euroneuro.2015.12.007. Epub 2015 Dec 10. Eur Neuropsychopharmacol. 2016. PMID: 26708319
-
Decreases in dopamine receptors but not in dopamine transporters in alcoholics.Alcohol Clin Exp Res. 1996 Dec;20(9):1594-8. doi: 10.1111/j.1530-0277.1996.tb05936.x. Alcohol Clin Exp Res. 1996. PMID: 8986209
-
Predominance of D2 receptors in mediating dopamine's effects in brain metabolism: effects of alcoholism.J Neurosci. 2013 Mar 6;33(10):4527-35. doi: 10.1523/JNEUROSCI.5261-12.2013. J Neurosci. 2013. PMID: 23467368 Free PMC article.
-
[Alcoholic detoxification in primary care].Aten Primaria. 2005 May 15;35(8):427-35. doi: 10.1157/13074800. Aten Primaria. 2005. PMID: 15882501 Free PMC article. Review. Spanish. No abstract available.
Cited by
-
Distinct cortico-striatal compartments drive competition between adaptive and automatized behavior.PLoS One. 2023 Mar 21;18(3):e0279841. doi: 10.1371/journal.pone.0279841. eCollection 2023. PLoS One. 2023. PMID: 36943842 Free PMC article.
-
Computational analysis of probabilistic reversal learning deficits in male subjects with alcohol use disorder.Front Psychiatry. 2022 Oct 19;13:960238. doi: 10.3389/fpsyt.2022.960238. eCollection 2022. Front Psychiatry. 2022. PMID: 36339830 Free PMC article.
-
Effects of chronic cocaine and ethanol self-administration on brain dopamine receptors in a rhesus monkey model of polysubstance abuse.Addict Biol. 2022 Sep;27(5):e13219. doi: 10.1111/adb.13219. Addict Biol. 2022. PMID: 36001440 Free PMC article.
-
Exploring regulation and function of dopamine D3 receptors in alcohol use disorder. A PET [11C]-(+)-PHNO study.Neuropsychopharmacology. 2021 Nov;46(12):2112-2120. doi: 10.1038/s41386-021-01095-2. Epub 2021 Aug 4. Neuropsychopharmacology. 2021. PMID: 34349232 Free PMC article.
-
Oxytocin and Addiction: Potential Glutamatergic Mechanisms.Int J Mol Sci. 2021 Feb 27;22(5):2405. doi: 10.3390/ijms22052405. Int J Mol Sci. 2021. PMID: 33673694 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical