doi: 10.1007/s00702-002-0749-9.
Different striatal dopamine D2 receptor occupancy in alcohol dependent patients with or without physical withdrawal symptoms --a study using IBZM-SPECT
Affiliations
- PMID: 12203049
- DOI: 10.1007/s00702-002-0749-9
Item in Clipboard
Different striatal dopamine D2 receptor occupancy in alcohol dependent patients with or without physical withdrawal symptoms --a study using IBZM-SPECT
J Neural Transm (Vienna).
2002 Sep.
Abstract
Ten male patients with type I alcohol dependency fulfilling DSM-IV criteria for alcohol dependency were investigated twice using IBZM-SPECT after alcohol withdrawal (day 2 and day 28 after withdrawal). Five patients had a history of physical withdrawal symptoms, 5 patients had no such history. The group with physical withdrawal symptoms showed higher IBZM binding in both scans indicating differences of dopaminergic neurotransmission in different subtypes of alcohol dependency.
Similar articles
-
Evaluation of [123I]IBZM pinhole SPECT for the detection of striatal dopamine D2 receptor availability in rats.Neuroimage. 2005 Feb 1;24(3):822-31. doi: 10.1016/j.neuroimage.2004.10.005. Epub 2004 Nov 24. Neuroimage. 2005. PMID: 15652317
-
No direct correlation between behaviorally active doses of the dopamine D2 agonist LY 171555 and displacement of [123I]IBZM as measured with SPECT in MPTP monkeys.Synapse. 1994 Jun;17(2):115-24. doi: 10.1002/syn.890170207. Synapse. 1994. PMID: 7916490
-
Striatal dopamine release after prefrontal repetitive transcranial magnetic stimulation in major depression: preliminary results of a dynamic [123I] IBZM SPECT study.J Psychiatr Res. 2006 Jun;40(4):307-14. doi: 10.1016/j.jpsychires.2005.09.001. Epub 2005 Nov 2. J Psychiatr Res. 2006. PMID: 16259998 Clinical Trial.
-
Alcohol and withdrawal: from animal research to clinical issues.Neurosci Biobehav Rev. 2003 May;27(3):189-97. doi: 10.1016/s0149-7634(03)00030-7. Neurosci Biobehav Rev. 2003. PMID: 12788332 Review.
-
Alcohol-related electrophysiology.Pharmacol Biochem Behav. 1980;13 Suppl 1:203-11. doi: 10.1016/s0091-3057(80)80032-3. Pharmacol Biochem Behav. 1980. PMID: 7017760 Review. No abstract available.
Cited by
-
Alcohol and basal ganglia circuitry: Animal models.Neuropharmacology. 2017 Aug 1;122:46-55. doi: 10.1016/j.neuropharm.2017.03.023. Epub 2017 Mar 21. Neuropharmacology. 2017. PMID: 28341206 Free PMC article. Review.
-
Perspectives on fronto-fugal circuitry from human imaging of alcohol use disorders.Neuropharmacology. 2017 Aug 1;122:189-200. doi: 10.1016/j.neuropharm.2017.01.018. Epub 2017 Jan 22. Neuropharmacology. 2017. PMID: 28118989 Free PMC article. Review.
-
Test-retest variability of [¹¹C]raclopride-binding potential in nontreatment-seeking alcoholics.Synapse. 2011 Jul;65(7):553-61. doi: 10.1002/syn.20874. Epub 2010 Dec 8. Synapse. 2011. PMID: 20963816 Free PMC article.
-
Selective alterations of brain dopamine D(2) receptor binding in cirrhotic patients: results of a (11)C-N-methylspiperone PET study.Metab Brain Dis. 2008 Sep;23(3):265-74. doi: 10.1007/s11011-008-9092-7. Epub 2008 Aug 7. Metab Brain Dis. 2008. PMID: 18686022
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
