Transimmunization, a novel approach for tumor immunotherapy
- PMID: 12126207
- DOI: 10.1016/s1473-0502(02)00014-9
Transimmunization, a novel approach for tumor immunotherapy
Abstract
This review describes our experience with the development of a novel form of immunotherapy that may represent the first practical and effective means of performing tumor-loaded dendritic cell (DC) immunotherapy. We have modified the highly successful extracorporeal photopheresis (ECP) treatment that has been used in the therapy of cutaneous T cell lymphoma (CTCL). autoimmune disease, transplantation rejection episodes and graft-versus-host disease to enhance its efficacy by the addition of an overnight incubation period. This adaption of ECP is termed "transimmunization (TI)" since the new therapy permits transfer of tumor antigens that have been previously poorly recognized to potent antigen presenting cells where the tumor epitopes can be displayed in the full context of major histocompatibility, co-stimulatory and adhesion molecules. The TI modification of ECP is a practical and safe means of rapidly inducing DC differentiation from peripheral blood monocytes in the presence of apoptotic tumor cells. Uptake of the apoptotic CTCL cells by the immature DC, in the presence of inflammatory cytokines, further drives their maturation into potent antigen presenting cells. Reinfusion of these tumor-loaded DC, that have access to the full spectrum of tumor antigens, has the potential to invoke an anti-tumor immune response in the recipient. Standard ECP has been a very useful form of immunotherapy and a modification of this approach that can enhance its ellicacy and utility should broaden its application to a larger variety of disorders including potentially the treatment of solid tumors and the modulation of the immune response in graft-versus-leukemia and graft-versus-host transplantation regimens. An understanding of the mechanism of ECP and TI will provide the physician with the ability to more finely tune the desired immune response and thereby, provide an enhanced immunotherapy for malignancy and other disorders of immunocompetence.
Similar articles
-
Transimmunization and the evolution of extracorporeal photochemotherapy.Transfus Apher Sci. 2002 Jun;26(3):181-90. doi: 10.1016/s1473-0502(02)00011-3. Transfus Apher Sci. 2002. PMID: 12126204 Review.
-
Efficient tumor antigen loading of dendritic antigen presenting cells by transimmunization.Technol Cancer Res Treat. 2002 Feb;1(1):65-9. doi: 10.1177/153303460200100109. Technol Cancer Res Treat. 2002. PMID: 12614179 Review.
-
Cutaneous T cell lymphoma: the helping hand of dendritic cells.Ann N Y Acad Sci. 2001 Sep;941:1-11. Ann N Y Acad Sci. 2001. PMID: 11594563 Review.
-
Clinical-scale generation of strongly CD83-expressing dendritic cells using extracorporeal photopheresis.Photodermatol Photoimmunol Photomed. 2007 Aug;23(4):113-9. doi: 10.1111/j.1600-0781.2007.00285.x. Photodermatol Photoimmunol Photomed. 2007. PMID: 17598863
-
Induction of anti-tumor CD8 T cell responses by experimental ECP-induced human dendritic antigen presenting cells.Transfus Apher Sci. 2016 Aug;55(1):146-52. doi: 10.1016/j.transci.2016.06.001. Epub 2016 Jun 6. Transfus Apher Sci. 2016. PMID: 27317354
Cited by
-
Psoralen: a narrative review of current and future therapeutic uses.J Cancer Res Clin Oncol. 2024 Mar 15;150(3):130. doi: 10.1007/s00432-024-05648-y. J Cancer Res Clin Oncol. 2024. PMID: 38489072 Free PMC article. Review.
-
What Does the Future Hold for Biomarkers of Response to Extracorporeal Photopheresis for Mycosis Fungoides and Sézary Syndrome?Cells. 2023 Sep 20;12(18):2321. doi: 10.3390/cells12182321. Cells. 2023. PMID: 37759543 Free PMC article. Review.
-
Extracorporeal Photopheresis: A Case of Immunotherapy Ahead of Its Time.Transfus Med Hemother. 2020 Jun;47(3):226-235. doi: 10.1159/000508479. Epub 2020 May 27. Transfus Med Hemother. 2020. PMID: 32595427 Free PMC article. Review.
-
Recommendations for Therapeutic Apheresis by the Section "Preparative and Therapeutic Hemapheresis" of the German Society for Transfusion Medicine and Immunohematology.Transfus Med Hemother. 2019 Dec;46(6):394-406. doi: 10.1159/000503937. Epub 2019 Nov 6. Transfus Med Hemother. 2019. PMID: 31933569 Free PMC article. Review.
-
A standardized methodical approach to characterize the influence of key parameters on the in vitro efficacy of extracorporeal photopheresis.PLoS One. 2019 Mar 1;14(3):e0212835. doi: 10.1371/journal.pone.0212835. eCollection 2019. PLoS One. 2019. PMID: 30822323 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources