Diagnosis and treatment of premenstrual dysphoria
- PMID: 11995774
Diagnosis and treatment of premenstrual dysphoria
Abstract
Premenstrual dysphoria (PMD) is a severe form of premenstrual syndrome afflicting 5% to 10% of all fertile women. Cardinal symptoms--appearing regularly between ovulation and menstruation and disappearing within a few days after the onset of the bleeding--are depressed mood, tension, affect lability, and irritability. Of these symptoms, irritability is often the most prominent. Serotonin reuptake inhibitors (SRIs), but not nonserotonergic antidepressants, reduce the symptoms of PMD effectively. The onset of action of SRIs is much shorter when used for PMD than when used for depression, enabling women with PMD to restrict medication use to the luteal phase of the cycle (so-called intermittent treatment). The findings that SRIs are effective for PMD--and that sexual dysfunction is the most frequent side effect during long-term treatment--both lend support for the hypothesis that a major role for brain serotonin is to modulate sex steroid-driven behavior.
Similar articles
-
[Serotonin uptake inhibitors provide rapid relief from premenstrual dysphoria. New findings shed light on how serotonin modulates sex hormone-related behavior].Lakartidningen. 2001 Aug 22;98(34):3524-30. Lakartidningen. 2001. PMID: 11571794 Review. Swedish.
-
Serotonin reuptake inhibitors for the treatment of premenstrual dysphoria.Int Clin Psychopharmacol. 1999 May;14 Suppl 2:S27-33. Int Clin Psychopharmacol. 1999. PMID: 10471170 Review.
-
Short onset of action of a serotonin reuptake inhibitor when used to reduce premenstrual irritability.Neuropsychopharmacology. 2009 Feb;34(3):585-92. doi: 10.1038/npp.2008.86. Epub 2008 Jul 2. Neuropsychopharmacology. 2009. PMID: 18596686 Clinical Trial.
-
Premenstrual syndrome.Lancet. 2008 Apr 5;371(9619):1200-10. doi: 10.1016/S0140-6736(08)60527-9. Lancet. 2008. PMID: 18395582 Free PMC article.
-
Placebo-controlled trial comparing intermittent and continuous paroxetine in premenstrual dysphoric disorder.Neuropsychopharmacology. 2007 Jan;32(1):153-61. doi: 10.1038/sj.npp.1301216. Epub 2006 Oct 11. Neuropsychopharmacology. 2007. PMID: 17035933 Clinical Trial.
Cited by
-
Reduced P300 amplitude is consistently associated with trait anhedonia across repeated assessments.Psychophysiology. 2022 Dec;59(12):e14127. doi: 10.1111/psyp.14127. Epub 2022 Jul 1. Psychophysiology. 2022. PMID: 35775190 Free PMC article.
-
Creatine Supplementation in Women's Health: A Lifespan Perspective.Nutrients. 2021 Mar 8;13(3):877. doi: 10.3390/nu13030877. Nutrients. 2021. PMID: 33800439 Free PMC article. Review.
-
Symptom-Onset Dosing of Sertraline for the Treatment of Premenstrual Dysphoric Disorder: A Randomized Clinical Trial.JAMA Psychiatry. 2015 Oct;72(10):1037-44. doi: 10.1001/jamapsychiatry.2015.1472. JAMA Psychiatry. 2015. PMID: 26351969 Free PMC article. Clinical Trial.
-
Exploring sex and gender differences in sleep health: a Society for Women's Health Research Report.J Womens Health (Larchmt). 2014 Jul;23(7):553-62. doi: 10.1089/jwh.2014.4816. Epub 2014 Jun 23. J Womens Health (Larchmt). 2014. PMID: 24956068 Free PMC article.
-
Premenstrual dysphoria and luteal stress in dominant-social-status female macaques.Evid Based Complement Alternat Med. 2013;2013:393862. doi: 10.1155/2013/393862. Epub 2013 Nov 28. Evid Based Complement Alternat Med. 2013. PMID: 24371458 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical