Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2002 May;76(10):4679-87.
doi: 10.1128/jvi.76.10.4679-4687.2002.

Viral late domains

Eric O Freed  1
Affiliations
Review

Viral late domains

Eric O Freed. J Virol. 2002 May.
No abstract available

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Location of L domains in retroviral Gag proteins and in the matrix proteins of the rhabdoviruses and filoviruses. The retroviral Gag proteins that harbor L domains are shown in red; matrix, capsid, and nucleocapsid proteins are depicted in green, blue, and yellow, respectively. L domain motifs (PTAP, PPXY, and YXXL) are indicated.
FIG. 2.
FIG. 2.
EM analysis of HIV-1 L domain defects. (A) Effect of HIV-1 L domain mutation on virus budding. Virus expression was directed by WT pNL4-3 and a p6 mutant derivative truncated at p6 amino acid 1 (L1Term [36]). Budding from HeLa cells and the Jurkat T-cell line is shown. Adapted from reference . (B) Effect of TSG-5′ overexpression on HIV-1 budding. HeLa cells were transfected with pNL4-3 alone (WT) or cotransfected with pNL4-3 plus TSG-5′ (WT + TSG-5′). Adapted with permission from reference . In panels A and B, closed arrows indicate virus particles tethered to the plasma membrane; open arrows highlight virion-virion tethers. Bar, 100 nm.
FIG. 3.
FIG. 3.
Schematic organization of TSG101 and Nedd4. Domains (described in the text) are indicated. Diagram is not intended to be to scale.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Accola, M. A., B. Strack, and H. G. Göttlinger. 2000. Efficient particle production by minimal Gag constructs which retain the carboxy-terminal domain of human immunodeficiency virus type 1 capsid-p2 and a late assembly domain. J. Virol. 74:5395-5402. - PMC - PubMed
    1. Babst, M., G. Odorizzi, E. J. Estepa, and S. D. Emr. 2000. Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking. Traffic 1:248-258. - PubMed
    1. Babst, M., B. Wendland, E. J. Estepa, and S. D. Emr. 1998. The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function. EMBO J. 17:2982-2993. - PMC - PubMed
    1. Bishop, N., and P. Woodman. 2000. ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking. Mol. Biol Cell. 11:227-239. - PMC - PubMed
    1. Bishop, N., and P. Woodman. 2001. TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes. J. Biol. Chem. 276:11735-11742. - PubMed

MeSH terms

LinkOut - more resources