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. 2002 Mar 22;108(6):837-47.
doi: 10.1016/s0092-8674(02)00685-2.

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

Chunming Liu  1 , Yiming Li, Mikhail Semenov, Chun Han, Gyeong Hun Baeg, Yi Tan, Zhuohua Zhang, Xinhua Lin, Xi He
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Free article

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

Chunming Liu et al. Cell. .
Free article

Abstract

Wnt regulation of beta-catenin degradation is essential for development and carcinogenesis. beta-catenin degradation is initiated upon amino-terminal serine/threonine phosphorylation, which is believed to be performed by glycogen synthase kinase-3 (GSK-3) in complex with tumor suppressor proteins Axin and adnomatous polyposis coli (APC). Here we describe another Axin-associated kinase, whose phosphorylation of beta-catenin precedes and is required for subsequent GSK-3 phosphorylation of beta-catenin. This "priming" kinase is casein kinase Ialpha (CKIalpha). Depletion of CKIalpha inhibits beta-catenin phosphorylation and degradation and causes abnormal embryogenesis associated with excessive Wnt/beta-catenin signaling. Our study uncovers distinct roles and steps of beta-catenin phosphorylation, identifies CKIalpha as a component in Wnt/beta-catenin signaling, and has implications to pathogenesis/therapeutics of human cancers and diabetes.

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