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. 2001 Oct 19;294(5542):605-9.
doi: 10.1126/science.1063916. Epub 2001 Sep 20.

Regulation of cutaneous malignancy by gammadelta T cells

M Girardi  1 , D E Oppenheim, C R Steele, J M Lewis, E Glusac, R Filler, P Hobby, B Sutton, R E Tigelaar, A C Hayday
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Free article

Regulation of cutaneous malignancy by gammadelta T cells

M Girardi et al. Science. .
Free article

Abstract

The localization of gammadelta T cells within epithelia suggests that these cells may contribute to the down-regulation of epithelial malignancies. We report that mice lacking gammadelta cells are highly susceptible to multiple regimens of cutaneous carcinogenesis. After exposure to carcinogens, skin cells expressed Rae-1 and H60, major histocompatibility complex-related molecules structurally resembling human MICA. Each of these is a ligand for NKG2d, a receptor expressed by cytolytic T cells and natural killer (NK) cells. In vitro, skin-associated NKG2d+ gammadelta cells killed skin carcinoma cells by a mechanism that was sensitive to blocking NKG2d engagement. Thus, local T cells may use evolutionarily conserved proteins to negatively regulate malignancy.

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