Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2001 Aug;7(8):941-6.
doi: 10.1038/90984.

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

T Yamauchi  1 , J Kamon, H Waki, Y Terauchi, N Kubota, K Hara, Y Mori, T Ide, K Murakami, N Tsuboyama-Kasaoka, O Ezaki, Y Akanuma, O Gavrilova, C Vinson, M L Reitman, H Kagechika, K Shudo, M Yoda, Y Nakano, K Tobe, R Nagai, S Kimura, M Tomita, P Froguel, T Kadowaki
Affiliations

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

T Yamauchi et al. Nat Med. 2001 Aug.

Abstract

Adiponectin is an adipocyte-derived hormone. Recent genome-wide scans have mapped a susceptibility locus for type 2 diabetes and metabolic syndrome to chromosome 3q27, where the gene encoding adiponectin is located. Here we show that decreased expression of adiponectin correlates with insulin resistance in mouse models of altered insulin sensitivity. Adiponectin decreases insulin resistance by decreasing triglyceride content in muscle and liver in obese mice. This effect results from increased expression of molecules involved in both fatty-acid combustion and energy dissipation in muscle. Moreover, insulin resistance in lipoatrophic mice was completely reversed by the combination of physiological doses of adiponectin and leptin, but only partially by either adiponectin or leptin alone. We conclude that decreased adiponectin is implicated in the development of insulin resistance in mouse models of both obesity and lipoatrophy. These data also indicate that the replenishment of adiponectin might provide a novel treatment modality for insulin resistance and type 2 diabetes.

PubMed Disclaimer

Comment in

  • You are what you secrete.
    Saltiel AR. Saltiel AR. Nat Med. 2001 Aug;7(8):887-8. doi: 10.1038/90911. Nat Med. 2001. PMID: 11479613 No abstract available.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

MeSH terms