Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria
- PMID: 11248802
- DOI: 10.1038/77783
Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria
Abstract
Paneth cells in mouse small intestinal crypts secrete granules rich in microbicidal peptides when exposed to bacteria or bacterial antigens. The dose-dependent secretion occurs within minutes and alpha-defensins, or cryptdins, account for 70% of the released bactericidal peptide activity. Gram-negative bacteria, Gram-positive bacteria, lipopolysaccharide, lipoteichoic acid, lipid A and muramyl dipeptide elicit cryptdin secretion. Live fungi and protozoa, however, do not stimulate degranulation. Thus intestinal Paneth cells contribute to innate immunity by sensing bacteria and bacterial antigens, and discharge microbicidal peptides at effective concentrations accordingly.
Comment in
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Paneth cells--guardians of the gut cell hatchery.Nat Immunol. 2000 Aug;1(2):99-100. doi: 10.1038/77884. Nat Immunol. 2000. PMID: 11248797 Review. No abstract available.
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