Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2000 Jul;14(7):1061-70; discussion 1070-4, 1076.

Cutaneous T-cell lymphoma: pathogenesis and treatment

M Girardi  1 , R L Edelson
Affiliations
  • PMID: 10929591
Free article
Review

Cutaneous T-cell lymphoma: pathogenesis and treatment

M Girardi et al. Oncology (Williston Park). 2000 Jul.
Free article

Abstract

Cutaneous T-cell lymphoma (CTCL) is a malignancy of a distinctive subset of T-helper cells designated "cutaneous T cells" because of their central role in the normal functioning of the skin immune system. Guided by selective adhesion molecules, activated/memory T cells of the skin immune system normally circulate among the skin, lymph nodes, and peripheral blood. Thus, a better understanding of the skin immune system, which normally functions to provide immunosurveillance against cutaneous pathogens and other insults, has led to a better understanding of the clinical spectrum, pathogenesis, staging, and management of CTCL. This article describes the major subtypes of CTCL and provides an update on the pathogenesis and treatment of this lymphoma.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

  • Interleukin-16 as a marker of Sézary syndrome onset and stage.
    Richmond J, Tuzova M, Parks A, Adams N, Martin E, Tawa M, Morrison L, Chaney K, Kupper TS, Curiel-Lewandrowski C, Cruikshank W. Richmond J, et al. J Clin Immunol. 2011 Feb;31(1):39-50. doi: 10.1007/s10875-010-9464-8. Epub 2010 Sep 28. J Clin Immunol. 2011. PMID: 20878214 Free PMC article.
  • A mouse model for the Sézary syndrome.
    Doebbeling U. Doebbeling U. J Exp Clin Cancer Res. 2010 Feb 11;29(1):11. doi: 10.1186/1756-9966-29-11. J Exp Clin Cancer Res. 2010. PMID: 20149229 Free PMC article.
  • FDG-PET/CT in the evaluation of cutaneous T-cell lymphoma.
    Kuo PH, McClennan BL, Carlson K, Wilson LD, Edelson RL, Heald PW, Girardi M. Kuo PH, et al. Mol Imaging Biol. 2008 Mar-Apr;10(2):74-81. doi: 10.1007/s11307-007-0127-y. Epub 2008 Jan 15. Mol Imaging Biol. 2008. PMID: 18196347

LinkOut - more resources