Voxel-based morphometry--the methods
- PMID: 10860804
- DOI: 10.1006/nimg.2000.0582
Voxel-based morphometry--the methods
Abstract
At its simplest, voxel-based morphometry (VBM) involves a voxel-wise comparison of the local concentration of gray matter between two groups of subjects. The procedure is relatively straightforward and involves spatially normalizing high-resolution images from all the subjects in the study into the same stereotactic space. This is followed by segmenting the gray matter from the spatially normalized images and smoothing the gray-matter segments. Voxel-wise parametric statistical tests which compare the smoothed gray-matter images from the two groups are performed. Corrections for multiple comparisons are made using the theory of Gaussian random fields. This paper describes the steps involved in VBM, with particular emphasis on segmenting gray matter from MR images with nonuniformity artifact. We provide evaluations of the assumptions that underpin the method, including the accuracy of the segmentation and the assumptions made about the statistical distribution of the data.
Copyright 2000 Academic Press.
Similar articles
-
Combining Segmented Grey and White Matter Images Improves Voxel-based Morphometry for the Case of Dilated Lateral Ventricles.Magn Reson Med Sci. 2018 Oct 10;17(4):293-300. doi: 10.2463/mrms.mp.2017-0127. Epub 2018 Jan 18. Magn Reson Med Sci. 2018. PMID: 29343657 Free PMC article.
-
Permutation and parametric tests for effect sizes in voxel-based morphometry of gray matter volume in brain structural MRI.Magn Reson Imaging. 2015 Dec;33(10):1299-1305. doi: 10.1016/j.mri.2015.07.014. Epub 2015 Aug 5. Magn Reson Imaging. 2015. PMID: 26253778 Free PMC article.
-
"Voxel-based morphometry" should not be used with imperfectly registered images.Neuroimage. 2001 Dec;14(6):1454-62. doi: 10.1006/nimg.2001.0770. Neuroimage. 2001. PMID: 11707101
-
[Understanding Voxel-Based Morphometry].Brain Nerve. 2017 May;69(5):505-511. doi: 10.11477/mf.1416200776. Brain Nerve. 2017. PMID: 28479527 Review. Japanese.
-
Regional deficits in brain volume in schizophrenia: a meta-analysis of voxel-based morphometry studies.Am J Psychiatry. 2005 Dec;162(12):2233-45. doi: 10.1176/appi.ajp.162.12.2233. Am J Psychiatry. 2005. PMID: 16330585 Review.
Cited by
-
Cortical grey matter volume differences in children with developmental coordination disorder compared to typically developing children.Front Hum Neurosci. 2024 May 17;18:1276057. doi: 10.3389/fnhum.2024.1276057. eCollection 2024. Front Hum Neurosci. 2024. PMID: 38826616 Free PMC article.
-
Trait-anxiety and glial-related neuroinflammation of the amygdala and its associated regions in Alzheimer's disease: A significant correlation.Brain Behav Immun Health. 2024 May 14;38:100795. doi: 10.1016/j.bbih.2024.100795. eCollection 2024 Jul. Brain Behav Immun Health. 2024. PMID: 38799793 Free PMC article.
-
Visual training after central retinal loss limits structural white matter degradation: an MRI study.Behav Brain Funct. 2024 May 24;20(1):13. doi: 10.1186/s12993-024-00239-w. Behav Brain Funct. 2024. PMID: 38789988 Free PMC article.
-
The impact of APOE ε4 in Alzheimer's disease: a meta-analysis of voxel-based morphometry studies.medRxiv [Preprint]. 2024 May 10:2024.05.10.24307165. doi: 10.1101/2024.05.10.24307165. medRxiv. 2024. PMID: 38766196 Free PMC article. Preprint.
-
Unstructured Group Support Enhances Compliance to Pharmacological Treatment by Improving Social Cognition in Patients with Bipolar Disorder: A Pilot fMRI Study.Psychiatry Clin Psychopharmacol. 2021 Sep 1;31(3):269-279. doi: 10.5152/pcp.2021.20019. eCollection 2021 Sep. Psychiatry Clin Psychopharmacol. 2021. PMID: 38765946 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical