doi: 10.1016/s0014-5793(00)01566-0.
Synergistic activation of the mkp-1 gene by protein kinase A signaling and USF, but not c-Myc
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- PMID: 10838075
- DOI: 10.1016/s0014-5793(00)01566-0
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Synergistic activation of the mkp-1 gene by protein kinase A signaling and USF, but not c-Myc
FEBS Lett.
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Abstract
Mitogen-activated protein kinase phosphatase 1 (MKP-1) is negatively regulating mitogen-activated protein kinases and is therefore involved in early signaling processes. The expression of the mkp-1 gene is induced by growth factors and stress. The promoters of the human and murine mkp-1 genes contain several conserved DNA binding elements, including two cAMP response elements and an E box. We observed that the upstream stimulatory factor (USF), but not c-Myc, activated mkp-1. USF synergized with protein kinase A, thus providing evidence for a role of the E box, during signal-regulated stimulation of mkp-1.
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