Central nervous system control of food intake
- PMID: 10766253
- DOI: 10.1038/35007534
Central nervous system control of food intake
Abstract
New information regarding neuronal circuits that control food intake and their hormonal regulation has extended our understanding of energy homeostasis, the process whereby energy intake is matched to energy expenditure over time. The profound obesity that results in rodents (and in the rare human case as well) from mutation of key signalling molecules involved in this regulatory system highlights its importance to human health. Although each new signalling pathway discovered in the hypothalamus is a potential target for drug development in the treatment of obesity, the growing number of such signalling molecules indicates that food intake is controlled by a highly complex process. To better understand how energy homeostasis can be achieved, we describe a model that delineates the roles of individual hormonal and neuropeptide signalling pathways in the control of food intake and the means by which obesity can arise from inherited or acquired defects in their function.
Similar articles
-
Neuropeptide Y, alpha-melanocyte-stimulating hormone, and monoamines in food intake regulation.Nutrition. 2005 Feb;21(2):269-79. doi: 10.1016/j.nut.2004.06.021. Nutrition. 2005. PMID: 15723758 Review.
-
[Obesity and the central nervous system regulation].Sheng Li Ke Xue Jin Zhan. 2001 Jan;32(1):45-51. Sheng Li Ke Xue Jin Zhan. 2001. PMID: 12545777 Review. Chinese.
-
Neuroendocrine regulation of food intake.Curr Opin Gastroenterol. 2008 Mar;24(2):223-9. doi: 10.1097/MOG.0b013e3282f3f4d8. Curr Opin Gastroenterol. 2008. PMID: 18301275
-
Integrative neurobiology of energy homeostasis-neurocircuits, signals and mediators.Front Neuroendocrinol. 2010 Jan;31(1):4-15. doi: 10.1016/j.yfrne.2009.08.002. Epub 2009 Sep 1. Front Neuroendocrinol. 2010. PMID: 19729032 Review.
-
Brain insulin and feeding: a bi-directional communication.Eur J Pharmacol. 2004 Apr 19;490(1-3):59-70. doi: 10.1016/j.ejphar.2004.02.044. Eur J Pharmacol. 2004. PMID: 15094073 Review.
Cited by
-
The Switchmaze: an open-design device for measuring motivation and drive switching in mice.Peer Community J. 2024 Apr 24;4:pcjournal.416. doi: 10.1101/2024.01.31.578188. Peer Community J. 2024. PMID: 38827787 Free PMC article.
-
Differentiating monogenic and syndromic obesities from polygenic obesity: Assessment, diagnosis, and management.Obes Pillars. 2024 Apr 22;11:100110. doi: 10.1016/j.obpill.2024.100110. eCollection 2024 Sep. Obes Pillars. 2024. PMID: 38766314 Free PMC article. Review.
-
A Comprehensive Review on Weight Gain following Discontinuation of Glucagon-Like Peptide-1 Receptor Agonists for Obesity.J Obes. 2024 May 10;2024:8056440. doi: 10.1155/2024/8056440. eCollection 2024. J Obes. 2024. PMID: 38765635 Free PMC article. Review.
-
Maternal choline supplementation mitigates premature foetal weight gain induced by an obesogenic diet, potentially linked to increased amniotic fluid leptin levels in rats.Sci Rep. 2024 May 18;14(1):11366. doi: 10.1038/s41598-024-62229-2. Sci Rep. 2024. PMID: 38762543 Free PMC article.
-
Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity.Signal Transduct Target Ther. 2024 Apr 26;9(1):103. doi: 10.1038/s41392-024-01810-7. Signal Transduct Target Ther. 2024. PMID: 38664368 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources