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Clinical Trial
. 1999 Dec;147(3):314-8.
doi: 10.1007/s002130051173.

Dopamine transporter and D2-receptor density in late-onset alcoholism

E Repo  1 , J T Kuikka, K A Bergström, J Karhu, J Hiltunen, J Tiihonen
Affiliations
Clinical Trial

Dopamine transporter and D2-receptor density in late-onset alcoholism

E Repo et al. Psychopharmacology (Berl). 1999 Dec.

Abstract

Rationale: Late onset type 1 alcoholism has been suggested to be associated with an underlying dopaminergic defect. Therefore, it is relevant to study both postsynaptic D2-receptor and presynaptic dopamine transporter (DAT) densities among alcoholics.

Objective: We investigated DAT densities, along with striatal and extrastriatal dopamine D2-receptor densities, in nine nonviolent late-onset male alcoholics, who had no major mental disorder nor antisocial personality disorder (ASPD), and nine healthy controls.

Methods: [123I]PE2I and [123I]epidepride were used in SPECT imaging.

Results: DAT occupancy ratios (striatum/cerebellum) were significantly lower among alcoholics than in controls. Extrastriatal D2-receptor occupancy ratios (temporal pole/cerebellum) were not significantly different between the groups.

Conclusions: Striatal presynaptic DAT densities are decreased among type 1 alcoholics, and this finding is not associated with recent alcohol abuse.

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