Atypical Spitz tumours and sentinel lymph node biopsy: a systematic review
- PMID: 24694641
- DOI: 10.1016/S1470-2045(13)70608-9
Atypical Spitz tumours and sentinel lymph node biopsy: a systematic review
Abstract
Sentinel lymph node biopsy has been proposed as a diagnostic method for estimation of the malignant potential of atypical Spitz tumours. However, although cell deposits are commonly detected in the sentinel lymph nodes of patients with atypical Spitz tumours, their prognosis is substantially better than that of patients with melanoma and positive sentinel lymph node biopsies. We did a systematic review of published reports to assess the role of sentinel lymph node biopsy as a prognostic method in the management of atypical Spitz tumours. The results of our analysis did not show any prognostic benefit of sentinel lymph node biopsy; having a positive sentinel lymph node does not seem to predict a poorer outcome for patients with atypical Spitz tumours. These findings indicate that, especially in the paediatric population, it might be prudent initially to use complete excision with clear margins and careful clinical follow-up in patients with atypical Spitz tumours.
Copyright © 2014 Elsevier Ltd. All rights reserved.
Comment in
-
Atypical Spitz tumours and sentinel lymph nodes.Lancet Oncol. 2014 Apr;15(4):377-8. doi: 10.1016/S1470-2045(13)70397-8. Lancet Oncol. 2014. PMID: 24694629 No abstract available.
Similar articles
-
Non-sentinel lymph node involvement in a patient with an atypical Spitz tumor and a positive sentinel node. Report of a case and review of the literature.J Cutan Pathol. 2009 May;36(5):586-90. doi: 10.1111/j.1600-0560.2008.01080.x. Epub 2009 Mar 30. J Cutan Pathol. 2009. PMID: 19476530 Review.
-
Atypical Spitz tumours and sentinel lymph nodes.Lancet Oncol. 2014 Apr;15(4):377-8. doi: 10.1016/S1470-2045(13)70397-8. Lancet Oncol. 2014. PMID: 24694629 No abstract available.
-
Atypical Spitz tumour with positive sentinel lymph node.J Plast Surg Hand Surg. 2013 Jun;47(3):234-7. doi: 10.3109/2000656X.2012.730486. Epub 2012 Dec 4. J Plast Surg Hand Surg. 2013. PMID: 23210497
-
The surgical management of Spitz naevi and atypical spitzoid neoplasms: A review of the literature.Surgeon. 2013 Aug;11(4):205-9. doi: 10.1016/j.surge.2013.01.001. Epub 2013 Mar 7. Surgeon. 2013. PMID: 23473747 Review.
-
Atypical Spitz tumors: facts and opinions on intranodal melanocytes.Hum Pathol. 2008 Mar;39(3):470; author reply 471. doi: 10.1016/j.humpath.2007.11.006. Hum Pathol. 2008. PMID: 18164369 No abstract available.
Cited by
-
Biologic Gray Zone of Melanocytic Tumors in Reality: Defining 'Non-Conventional' Melanocytic Tumors.Dermatol Pract Concept. 2024 Apr 1;14(2):e2024149. doi: 10.5826/dpc.1402a149. Dermatol Pract Concept. 2024. PMID: 38810070 Free PMC article. No abstract available.
-
Pediatric Atypical Melanocytic Proliferations: Single-Site Retrospective Cohort Assessment of Treatment and Long-Term Follow-Up.Cancers (Basel). 2023 Dec 12;15(24):5804. doi: 10.3390/cancers15245804. Cancers (Basel). 2023. PMID: 38136349 Free PMC article.
-
Paediatric Spitzoid Neoplasms: 10-Year Retrospective Study Characterizing Histological, Clinical, Dermoscopic Presentation and FISH Test Results.Diagnostics (Basel). 2023 Jul 15;13(14):2380. doi: 10.3390/diagnostics13142380. Diagnostics (Basel). 2023. PMID: 37510125 Free PMC article.
-
The Spectrum of Spitz Melanocytic Lesions: From Morphologic Diagnosis to Molecular Classification.Front Oncol. 2022 Jun 7;12:889223. doi: 10.3389/fonc.2022.889223. eCollection 2022. Front Oncol. 2022. PMID: 35747831 Free PMC article. Review.
-
The spectrum of melanocytic nevi and their clinical implications.J Dtsch Dermatol Ges. 2022 Apr;20(4):483-504. doi: 10.1111/ddg.14776. J Dtsch Dermatol Ges. 2022. PMID: 35446494 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
