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. 2014 Apr;134(4):1067-1074.
doi: 10.1038/jid.2013.429. Epub 2013 Oct 15.

NRAS mutation is the sole recurrent somatic mutation in large congenital melanocytic nevi

Christelle Charbel  1 , Romain H Fontaine  1 , Gabriel G Malouf  2 , Arnaud Picard  3 , Natacha Kadlub  3 , Nizar El-Murr  1 , Alexandre How-Kit  4 , Xiaoping Su  5 , Aurore Coulomb-L'Hermine  6 , Jorg Tost  7 , Samia Mourah  8 , Selim Aractingi  9 , Sarah Guégan  10
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Free article

NRAS mutation is the sole recurrent somatic mutation in large congenital melanocytic nevi

Christelle Charbel et al. J Invest Dermatol. 2014 Apr.
Free article

Abstract

Congenital melanocytic nevus (CMN) is a particular melanocytic in utero proliferation characterized by an increased risk of melanoma transformation during infancy or adulthood. NRAS and BRAF mutations have consistently been reported in CMN samples, but until recently results have been contradictory. We therefore studied a series of large and giant CMNs and compared them with small and medium CMNs using Sanger sequencing, pyrosequencing, high-resolution melting analysis, and mutation enrichment by an enhanced version of ice-COLD-PCR. Large-giant CMNs displayed NRAS mutations in 94.7% of cases (18/19). At that point, the role of additional mutations in CMN pathogenesis had to be investigated. We therefore performed exome sequencing on five specimens of large-giant nevi. The results showed that NRAS mutation was the sole recurrent somatic event found in such melanocytic proliferations. The genetic profile of small-medium CMNs was significantly different, with 70% of cases bearing NRAS mutations and 30% showing BRAF mutations. These findings strongly suggest that NRAS mutations are sufficient to drive melanocytic benign proliferations in utero.

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References

    1. J Invest Dermatol. 2011 May;131(5):1129-38 - PubMed
    1. Pigment Cell Melanoma Res. 2011 Aug;24(4):666-72 - PubMed
    1. Dermatol Res Pract. 2011;2011:463184 - PubMed
    1. Nat Genet. 1999 Dec;23(4):452-6 - PubMed
    1. J Am Acad Dermatol. 2006 May;54(5):767-77 - PubMed

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