Incidence of basal cell and squamous cell carcinomas in a population younger than 40 years
- PMID: 16091570
- DOI: 10.1001/jama.294.6.681
Incidence of basal cell and squamous cell carcinomas in a population younger than 40 years
Abstract
Context: The incidence of nonmelanoma skin cancer is increasing rapidly among elderly persons, but little is known about its incidence in the population younger than 40 years.
Objectives: To estimate the sex- and age-specific incidences of basal cell carcinoma and squamous cell carcinoma in persons younger than 40 years in Olmsted County, Minnesota, and to evaluate change in incidence over time; to describe the clinical presentation, rate of recurrence and metastasis, and histologic characteristics of these tumors in this population-based sample.
Design: Population-based retrospective incidence case review.
Setting: Residents of Olmsted County, Minnesota, a population with comprehensive medical records captured through the Rochester Epidemiology Project.
Participants: Patients younger than 40 years with basal cell carcinoma or squamous cell carcinoma diagnosed between 1976 and 2003.
Main outcome measures: Incident basal cell carcinomas and squamous cell carcinomas and change in incidence of these tumors over time.
Results: During the study period, 451 incident basal cell carcinomas were diagnosed in 417 patients and 70 incident squamous cell carcinomas were diagnosed in 68 patients. Of these tumors, 328 were histologically confirmed basal cell carcinomas and 51 were histologically confirmed squamous cell carcinomas. Overall, the age-adjusted incidence of basal cell carcinoma per 100,000 persons was 25.9 (95% confidence interval [CI], 22.6-29.2) for women and 20.9 (95% CI, 17.8-23.9) for men. The incidence of basal cell carcinoma increased significantly during the study period among women (P<.001) but not men (P = .19). Nodular basal cell carcinoma was the most common histologic subtype; 43.0% of tumors were solely nodular basal cell carcinoma and 11.0% had a mixed composition, including the nodular subtype. The incidence of squamous cell carcinoma was similar in men and women, with an average age- and sex-adjusted incidence per 100 000 persons of 3.9 (95% CI, 3.0-4.8); the incidence of squamous cell carcinoma increased significantly over the study period among both women (P = .01) and men (P = .04).
Conclusions: This population-based study demonstrated an increase in the incidence of nonmelanoma skin cancer among young women and men residing in Olmsted County, Minnesota. There was a disproportionate increase in basal cell carcinoma in young women. This increase may lead to an exponential increase in the overall occurrence of nonmelanoma skin cancers over time as this population ages, which emphasizes the need to focus on skin cancer prevention in young adults.
Comment in
-
Basal cell and squamous cell carcinoma in persons younger than 40 years.JAMA. 2006 Jan 18;295(3):278-9; author reply 279-81. doi: 10.1001/jama.295.3.278-c. JAMA. 2006. PMID: 16418456 No abstract available.
-
Basal cell and squamous cell carcinoma in persons younger than 40 years.JAMA. 2006 Jan 18;295(3):278; author reply 279-81. doi: 10.1001/jama.295.3.278-b. JAMA. 2006. PMID: 16418457 No abstract available.
-
Basal cell and squamous cell carcinoma in persons younger than 40 years.JAMA. 2006 Jan 18;295(3):278; author reply 279-81. doi: 10.1001/jama.295.3.278-a. JAMA. 2006. PMID: 16418458 No abstract available.
-
Basal cell and squamous cell carcinoma in persons younger than 40 years.JAMA. 2006 Jan 18;295(3):279; author reply 279-81. doi: 10.1001/jama.295.3.279-a. JAMA. 2006. PMID: 16418459 No abstract available.
Similar articles
-
Incidence and Trends of Basal Cell Carcinoma and Cutaneous Squamous Cell Carcinoma: A Population-Based Study in Olmsted County, Minnesota, 2000 to 2010.Mayo Clin Proc. 2017 Jun;92(6):890-898. doi: 10.1016/j.mayocp.2017.02.015. Epub 2017 May 15. Mayo Clin Proc. 2017. PMID: 28522111 Free PMC article.
-
Nonmelanoma skin cancer: is the incidence really increasing among patients younger than 40? A reexamination using 25 years of U.S. outpatient data.Dermatol Surg. 2006 Dec;32(12):1473-9. doi: 10.1111/j.1524-4725.2006.32358.x. Dermatol Surg. 2006. PMID: 17199655
-
Epidemiologic characteristics and clinical course of patients with malignant eyelid tumors in an incidence cohort in Olmsted County, Minnesota.Ophthalmology. 1999 Apr;106(4):746-50. doi: 10.1016/S0161-6420(99)90161-6. Ophthalmology. 1999. PMID: 10201597
-
Trends in the population-based incidence of squamous cell carcinoma of the skin first diagnosed between 1984 and 1992.Arch Dermatol. 1997 Jun;133(6):735-40. Arch Dermatol. 1997. PMID: 9197827 Review.
-
Trends in Non-Melanoma Skin Cancer (Basal Cell Carcinoma and Squamous Cell Carcinoma) in Canada: A Descriptive Analysis of Available Data.J Cutan Med Surg. 2016 Mar-Apr;20(2):166-75. doi: 10.1177/1203475415610106. Epub 2015 Oct 12. J Cutan Med Surg. 2016. PMID: 26458408 Review.
Cited by
-
Extra-Anogenital Giant Cutaneous Squamous Cell Carcinomas.Life (Basel). 2024 Mar 21;14(3):421. doi: 10.3390/life14030421. Life (Basel). 2024. PMID: 38541745 Free PMC article.
-
A Comprehensive Review of Various Therapeutic Strategies for the Management of Skin Cancer.ACS Omega. 2024 Feb 22;9(9):10030-10048. doi: 10.1021/acsomega.3c09780. eCollection 2024 Mar 5. ACS Omega. 2024. PMID: 38463249 Free PMC article. Review.
-
Recurrent Basal Cell Carcinoma (BCC) of the Forearm: A Case Report.Cureus. 2023 Jun 11;15(6):e40247. doi: 10.7759/cureus.40247. eCollection 2023 Jun. Cureus. 2023. PMID: 37440822 Free PMC article.
-
The Role of Sex and Gender in Dermatology - From Pathogenesis to Clinical Implications.J Cutan Med Surg. 2023 Jul-Aug;27(4):NP1-NP36. doi: 10.1177/12034754231177582. Epub 2023 Jul 4. J Cutan Med Surg. 2023. PMID: 37401812 Free PMC article. Review.
-
Cutaneous Squamous Cell Carcinoma in Immunocompromised Patients-A Comparison between Different Immunomodulating Conditions.Cancers (Basel). 2023 Mar 14;15(6):1764. doi: 10.3390/cancers15061764. Cancers (Basel). 2023. PMID: 36980651 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical