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Assay systems are methods that are used to measure the presence, amount or activity of a substance e.g. a drug, cell type or cell component. A wide range of experimental methods are used to measure different components of organic samples in assay systems.
Phage therapy often relies on labour-intensive and time-consuming methods that could lead to delays in medical treatment. Here, authors describe an all-in-one solution for navigating multiple, large, decentralized biobanks, allowing for rapid high-throughput phage susceptibility testing.
New strategies are needed to address treatment resistance in glioblastoma. Here the authors show that TP53-mutant glioblastomas rely upon ATM-dependent double strand break repair to resist DNA-damaging therapy, rendering them vulnerable to drug combinations employing ATM inhibitors.
The discovery of antibodies that bind with high affinity to clinically relevant antigens can be sped up by leveraging next-generation sequencing to screen hundreds of millions of antibody–antigen interactions.
Pharmaceutical companies continue to advocate for the use of in vitro models towards the reduction of animal use in drug discovery and development while acknowledging that further advancements are needed to heighten the models’ current state of readiness.
DNA-based molecular computation allows for the simultaneous detection of multiple types of biomarker, as shown for the accurate identification of prostate cancer in serum samples on the basis of specific RNAs, proteins and small molecules.
INSPECTR is a technique for detecting nucleic acids that couples the sensitivity and specificity of nucleic acid splinted ligation with the versatile readouts of cell-free gene expression. The result is an ambient-temperature workflow that enables the detection of pathogenic viruses at low copy numbers.