Emulsions underpin a wide range of important natural phenomena and many technological applications. However, it remains challenging to create emulsion droplets with specific internal structures. Now, a method has been developed to create macromolecular emulsions with custom architectures by applying non-equilibrium thermodynamic principles to condensate formation.
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References
Fare, C. M., Villani, A., Drake, L. E. & Shorter, J. Higher-order organization of biomolecular condensates. Open Biol. 11, 210137 (2021). This review article outlines the different condensate architectures observed in cells.
Chu, L.-Y., Utada, A. S., Shah, R. K., Kim, J.-W. & Weitz, D. A. Controllable monodisperse multiple emulsions. Angew. Chem. Int. Ed. 47, 8970–8974 (2007). This paper reports a method for using microfluidics to make multiphase emulsions with complex structures.
Mason, A. F., Buddingh’, B. C., Williams, D. S. & van Hest, J. C. M. Hierarchical self-assembly of a copolymer-stabilized coacervate protocell. J. Am. Chem. Soc. 139, 17309–17312 (2017). This article introduces the amylose condensate model system.
Erkamp, N. A. et al. Spatially non-uniform condensates emerge from dynamically arrested phase separation. Nat. Commun. 14, 684 (2023). This article reports the diffusion-induced nucleation of droplets in condensates.
Dai, Y. et al. Interface of biomolecular condensates modulates redox reactions. Chem 9, 1594–1609 (2023). This article reports that the interface of condensates can catalyze redox reactions.
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This is a summary of: Erkamp, N. A. et al. Biomolecular condensates with complex architectures via controlled nucleation. Nat. Chem. Eng. https://doi.org/10.1038/s44286-024-00077-7 (2024).
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Structuring emulsion droplets out of equilibrium. Nat Chem Eng 1, 398–399 (2024). https://doi.org/10.1038/s44286-024-00083-9
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DOI: https://doi.org/10.1038/s44286-024-00083-9
