Tonic inhibitory conductances mediated by GABA A receptors have now been identified and
characterized in many different brain regions. Most experimental studies of tonic GABAergic …

Tonic inhibition has emerged as a key regulator of neuronal excitability in the CNS. Thalamic
relay neurons of the dorsal lateral geniculate nucleus (dLGN) exhibit a tonic GABA A …

Nitrous oxide, xenon, and cyclopropane are anesthetic gases that have a distinct pharmacological
profile. Whereas the molecular basis for their anesthetic actions remains unclear, they …

High-affinity extrasynaptic GABA A receptors (GABA A Rs) are a prominent feature of cerebellar
granule neurons and thalamic relay neurons. In both cell types, the presence of synaptic …

Tonic inhibition mediated by extrasynaptic GABA A receptors ( GABA A R s) is an important
regulator of neuronal excitability. Phosphorylation by protein kinase C ( PKC ) provides a key …

Brain inhibition is a vital process for controlling and sculpting the excitability of the central
nervous system in healthy individuals. This level of control is provided over several timescales …

The time-dependent integration of excitatory and inhibitory synaptic currents is an important
process for shaping the input–output profiles of individual excitable cells, and therefore the …

γ-aminobutyric acid type A receptors (GABA A Rs) are important components of the central
nervous system and they are functionally tasked with controlling neuronal excitability. These …

GABA A receptors are vital for controlling neuronal excitability and can display significant
levels of constitutive activity that contributes to tonic inhibition. However, the mechanisms …

We have discovered that adult thalamocortical relay neurones exhibit a sustained enhancement
of synaptic inhibition triggered by transient action potential firing of a single thalamic …