Evidence for social anxiety and impaired social cognition in a mouse model of fragile X syndrome
- PMID: 18410169
- DOI: 10.1037/0735-7044.122.2.293
Evidence for social anxiety and impaired social cognition in a mouse model of fragile X syndrome
Abstract
This study assessed social behavior in a mouse model of Fragile X syndrome (FXS), the Fmr1 (tm1Cgr) or Fmr1 "knockout" (KO) mouse. Both the KO and wild-type (WT) mice preferred to be near a novel conspecific than to be alone. However, during the initial interaction with a novel conspecific, (1) a greater proportion of the KO mice exhibited high levels of grooming; and (2) the average duration of nose contact with the stimulus mouse was significantly shorter for the KO mice, both indicative of increased arousal and/or anxiety. Both groups exhibited a robust novelty preference when the novel animal was a "preferred" mouse. However, when the novel mouse was a "nonpreferred" animal, both groups showed a diminished novelty preference but this effect was more pronounced for the WT mice. This blunted negative reaction of the KO mice to a nonpreferred animal may indicate that they were less proficient than controls in distinguishing between positive and negative social interactions. These findings provide support for the use of this animal model to study the autistic features of FXS and autism spectrum disorders.
Comment in
-
Social behavior phenotypes in fragile X syndrome, autism, and the Fmr1 knockout mouse: theoretical comment on McNaughton et al. (2008).Behav Neurosci. 2008 Apr;122(2):483-9. doi: 10.1037/0735-7044.122.2.483. Behav Neurosci. 2008. PMID: 18410188 Review.
Similar articles
-
A mouse model of fragile X syndrome exhibits heightened arousal and/or emotion following errors or reversal of contingencies.Dev Psychobiol. 2008 Jul;50(5):473-85. doi: 10.1002/dev.20308. Dev Psychobiol. 2008. PMID: 18551464
-
Social behavior phenotypes in fragile X syndrome, autism, and the Fmr1 knockout mouse: theoretical comment on McNaughton et al. (2008).Behav Neurosci. 2008 Apr;122(2):483-9. doi: 10.1037/0735-7044.122.2.483. Behav Neurosci. 2008. PMID: 18410188 Review.
-
Advances in behavioral genetics: mouse models of autism.Mol Psychiatry. 2008 Jan;13(1):4-26. doi: 10.1038/sj.mp.4002082. Epub 2007 Sep 11. Mol Psychiatry. 2008. PMID: 17848915 Review.
-
Fmr1 knockout mice are impaired in a leverpress escape/avoidance task.Genes Brain Behav. 2006 Aug;5(6):467-71. doi: 10.1111/j.1601-183X.2005.00183.x. Genes Brain Behav. 2006. PMID: 16923151
-
Altered anxiety-related and social behaviors in the Fmr1 knockout mouse model of fragile X syndrome.Genes Brain Behav. 2005 Oct;4(7):420-30. doi: 10.1111/j.1601-183X.2005.00123.x. Genes Brain Behav. 2005. PMID: 16176388
Cited by
-
Translational modulator ISRIB alleviates synaptic and behavioral phenotypes in Fragile X syndrome.iScience. 2024 Feb 16;27(4):109259. doi: 10.1016/j.isci.2024.109259. eCollection 2024 Apr 19. iScience. 2024. PMID: 38510125 Free PMC article.
-
SRC family kinase inhibition rescues molecular and behavioral phenotypes, but not protein interaction network dynamics, in a mouse model of Fragile X syndrome.Mol Psychiatry. 2024 May;29(5):1392-1405. doi: 10.1038/s41380-024-02418-7. Epub 2024 Jan 31. Mol Psychiatry. 2024. PMID: 38297084
-
Cognition, academic achievement, and adaptive behavior in school-aged girls with fragile X syndrome.Res Dev Disabil. 2023 Dec;143:104622. doi: 10.1016/j.ridd.2023.104622. Epub 2023 Nov 6. Res Dev Disabil. 2023. PMID: 37939495
-
Methyl-CpG binding domain 2 (Mbd2) is an epigenetic regulator of autism-risk genes and cognition.Transl Psychiatry. 2023 Jul 13;13(1):259. doi: 10.1038/s41398-023-02561-9. Transl Psychiatry. 2023. PMID: 37443311 Free PMC article.
-
From circuits to behavior: Amygdala dysfunction in fragile X syndrome.Front Integr Neurosci. 2023 Mar 9;17:1128529. doi: 10.3389/fnint.2023.1128529. eCollection 2023. Front Integr Neurosci. 2023. PMID: 36969493 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials