Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance
- PMID: 11343119
- DOI: 10.1038/35051086
Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance
Abstract
Many neurons receive a continuous, or 'tonic', synaptic input, which increases their membrane conductance, and so modifies the spatial and temporal integration of excitatory signals. In cerebellar granule cells, although the frequency of inhibitory synaptic currents is relatively low, the spillover of synaptically released GABA (gamma-aminobutyric acid) gives rise to a persistent conductance mediated by the GABA A receptor that also modifies the excitability of granule cells. Here we show that this tonic conductance is absent in granule cells that lack the alpha6 and delta-subunits of the GABAA receptor. The response of these granule cells to excitatory synaptic input remains unaltered, owing to an increase in a 'leak' conductance, which is present at rest, with properties characteristic of the two-pore-domain K+ channel TASK-1 (refs 9,10,11,12). Our results highlight the importance of tonic inhibition mediated by GABAA receptors, loss of which triggers a form of homeostatic plasticity leading to a change in the magnitude of a voltage-independent K + conductance that maintains normal neuronal behaviour.
Comment in
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Neurobiology. Background inhibition to the fore.Nature. 2001 Jan 4;409(6816):24-5, 27. doi: 10.1038/35051187. Nature. 2001. PMID: 11343093 No abstract available.
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