The model and interior sets of the submarine cost producer Irwin Allen $400,000, so he was naturally quite keen to get some further use out of them. Since the film was a hit, he was able to convince ABC-TV to turn it into a series, which became the longest-running one he ever had.
Del Monroe appeared in the original film as Kowski as well as the regular character with a similar name, Kowalski, on Voyage to the Bottom of the Sea (1964).
During production, Irwin Allen asked the Navy for advice to help in making the film. However, the Navy refused because its nuclear program was just beginning in 1961 and was top secret. They didn't want any information getting to the Soviet Union.
Robert Easton, who played radio operator "Sparks," was the voice of Lieutenant George Lee 'Phones' Sheridan in Stingray (1964), another underwater vessel.
Irwin Allen: The voice-over for the newscasts that crew members watch, detailing the burning forests, etc.