Abstract
Chronic heart failure is a major public health problem causing considerable morbidity and mortality. Recent studies have shown that an elevated plasma level of homocysteine is a strong independent risk factor for heart failure, in addition to atherosclerotic disease. Preclinical studies have demonstrated that induced hyperhomocysteinemia acts via multiple pathogenic mechanisms, including inflammation and oxidative stress, to promote adverse cardiac remodeling and failure. However, clinical studies have not conclusively shown a causative relation between hyperhomocysteinemia and cardiovascular disease. This article will review current data concerning homocysteine and its pathogenic relationship to heart failure.
Keywords: Homocysteine, Heart Failure, Remodeling, Cardiovascular Disease, morbidity, mortality, atherosclerotic disease, oxidative stress, atherothrombotic, spironolactone, hypertension, diabetes mellitus, obesity, B-type, natriuretic peptide, hyperuricaemia, echocardiographic signs, diastolic diameter, methionine, cystathionine, methyltetrahydrofolate, adenosylmethionine, neurohormonal model, angiotensin-converting enzyme, fibrosis, tumor necrosis, myocardium, Interleukins-1, matrix metalloproteinases, Cathepsin G, anti-oxidant vitamin, Coronary artery disease
Cardiovascular & Hematological Disorders-Drug Targets
Title: Homocysteine, Cardiovascular Inflammation, and Myocardial Remodeling
Volume: 10 Issue: 4
Author(s): Jennifer M. Finch and Jacob Joseph
Affiliation:
Keywords: Homocysteine, Heart Failure, Remodeling, Cardiovascular Disease, morbidity, mortality, atherosclerotic disease, oxidative stress, atherothrombotic, spironolactone, hypertension, diabetes mellitus, obesity, B-type, natriuretic peptide, hyperuricaemia, echocardiographic signs, diastolic diameter, methionine, cystathionine, methyltetrahydrofolate, adenosylmethionine, neurohormonal model, angiotensin-converting enzyme, fibrosis, tumor necrosis, myocardium, Interleukins-1, matrix metalloproteinases, Cathepsin G, anti-oxidant vitamin, Coronary artery disease
Abstract: Chronic heart failure is a major public health problem causing considerable morbidity and mortality. Recent studies have shown that an elevated plasma level of homocysteine is a strong independent risk factor for heart failure, in addition to atherosclerotic disease. Preclinical studies have demonstrated that induced hyperhomocysteinemia acts via multiple pathogenic mechanisms, including inflammation and oxidative stress, to promote adverse cardiac remodeling and failure. However, clinical studies have not conclusively shown a causative relation between hyperhomocysteinemia and cardiovascular disease. This article will review current data concerning homocysteine and its pathogenic relationship to heart failure.
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Cite this article as:
M. Finch Jennifer and Joseph Jacob, Homocysteine, Cardiovascular Inflammation, and Myocardial Remodeling, Cardiovascular & Hematological Disorders-Drug Targets 2010; 10 (4) . https://dx.doi.org/10.2174/187152910793743887
DOI https://dx.doi.org/10.2174/187152910793743887 |
Print ISSN 1871-529X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4063 |
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