Anatomic basis for differential regulation of the rostrolateral peri–locus coeruleus region by limbic afferents
EJ Van Bockstaele, J Peoples, RJ Valentino�- Biological psychiatry, 1999 - Elsevier
Background: Neurochemical and electrophysiological studies indicate that the locus
coeruleus (LC)-norepinephrine system is activated by physiological and external stressors.
This activation is mediated in part by corticotropin-releasing factor (CRF), the hypothalamic
neurohormone that initiates the endocrine response to stress. We have previously shown
that the central nucleus of the amygdala (CNA) provides CRF afferents to noradrenergic
processes in the peri-LC area that may serve to integrate emotional and cognitive responses�…
coeruleus (LC)-norepinephrine system is activated by physiological and external stressors.
This activation is mediated in part by corticotropin-releasing factor (CRF), the hypothalamic
neurohormone that initiates the endocrine response to stress. We have previously shown
that the central nucleus of the amygdala (CNA) provides CRF afferents to noradrenergic
processes in the peri-LC area that may serve to integrate emotional and cognitive responses�…