A two-year longitudinal MRI study of the corpus callosum in autism
TW Frazier, MS Keshavan, NJ Minshew…�- Journal of autism and�…, 2012 - Springer
Journal of autism and developmental disorders, 2012•Springer
A growing body of literature has identified size reductions of the corpus callosum (CC) in
autism. However, to our knowledge, no published studies have reported on the growth of CC
volumes in youth with autism. Volumes of the total CC and its sub-divisions were obtained
from 23 male children with autism and 23 age-and gender-matched controls at baseline and
2-year follow-up. Persistent reductions in total CC volume were observed in participants with
autism relative to controls. Only the rostral body subdivision showed a normalization of size�…
autism. However, to our knowledge, no published studies have reported on the growth of CC
volumes in youth with autism. Volumes of the total CC and its sub-divisions were obtained
from 23 male children with autism and 23 age-and gender-matched controls at baseline and
2-year follow-up. Persistent reductions in total CC volume were observed in participants with
autism relative to controls. Only the rostral body subdivision showed a normalization of size�…
Abstract
A growing body of literature has identified size reductions of the corpus callosum (CC) in autism. However, to our knowledge, no published studies have reported on the growth of CC volumes in youth with autism. Volumes of the total CC and its sub-divisions were obtained from 23 male children with autism and 23 age- and gender-matched controls at baseline and 2-year follow-up. Persistent reductions in total CC volume were observed in participants with autism relative to controls. Only the rostral body subdivision showed a normalization of size over time. Persistent reductions are consistent with the diagnostic stability and life-long impairment observed in many individuals with autism. Multi-modal imaging studies are needed to identify specific fiber tracks contributing to CC reductions.
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