Non-alcoholic fatty liver disease (NAFLD) is now recognised as the most common liver
disease worldwide. It encompasses a broad spectrum of conditions, from simple steatosis,
through non-alcoholic steatohepatitis, to fibrosis and ultimately cirrhosis and hepatocellular
carcinoma. A hallmark of NAFLD is the substantial inter-patient variation in disease
progression. NAFLD is considered a complex disease trait such that interactions between
the environment and a susceptible polygenic host background determine disease�…