Oxidative damage accumulation in macromolecules has been considered as causative of
cellular damage and pathology. Considering early observations of Gershman that oxygen
free radicals exist in vivo in the 1950s Denham Harman proposed seminal that reactive
oxygen species are a cause of aging (free radical theory of aging). The goal of this review is
to analyze recent findings related Harman's theory. In this regard, we have focused primarily
on theoretical analyses of oxidative stress and their biological impact. It is not the only�…