The Met allele of the BDNF Val66Met polymorphism is associated with increased BDNF serum concentrations
UE Lang, R Hellweg, T Sander, J Gallinat�- Molecular psychiatry, 2009 - nature.com
UE Lang, R Hellweg, T Sander, J Gallinat
Molecular psychiatry, 2009•nature.comThe brain-derived neurotrophic factor (BDNF) hypothesis of depression postulates that a
loss of BDNF function is directly involved in the pathophysiology of depression and its
restoration may underlie the therapeutic efficacy of antidepressant treatments (for recent
review see Groves1). The hypothesis is in line with observations that BDNF concentrations
in humans are decreased in major depressed patients and healthy humans with depression-
related personality traits and are increased after antidepressant treatment. 2, 3
loss of BDNF function is directly involved in the pathophysiology of depression and its
restoration may underlie the therapeutic efficacy of antidepressant treatments (for recent
review see Groves1). The hypothesis is in line with observations that BDNF concentrations
in humans are decreased in major depressed patients and healthy humans with depression-
related personality traits and are increased after antidepressant treatment. 2, 3
The brain-derived neurotrophic factor (BDNF) hypothesis of depression postulates that a loss of BDNF function is directly involved in the pathophysiology of depression and its restoration may underlie the therapeutic efficacy of antidepressant treatments (for recent review see Groves1). The hypothesis is in line with observations that BDNF concentrations in humans are decreased in major depressed patients and healthy humans with depression-related personality traits and are increased after antidepressant treatment. 2, 3
nature.com