Thyroid diseases and adverse pregnancy outcomes in a contemporary US cohort
The Journal of Clinical Endocrinology & Metabolism, 2013•academic.oup.com
Context: Thyroid diseases are inconsistently reported to increase risk for pregnancy
complications. Objective: The objective of this study was to study pregnancy complications
associated with common and uncommon thyroid diseases. Design, Setting, and Participants:
We analyzed singleton pregnancies (N= 223 512) from a retrospective US cohort, the
Consortium on Safe Labor (2002–2008). Thyroid diseases and outcomes were derived from
electronic medical records. Multivariable logistic regression with generalized estimating�…
complications. Objective: The objective of this study was to study pregnancy complications
associated with common and uncommon thyroid diseases. Design, Setting, and Participants:
We analyzed singleton pregnancies (N= 223 512) from a retrospective US cohort, the
Consortium on Safe Labor (2002–2008). Thyroid diseases and outcomes were derived from
electronic medical records. Multivariable logistic regression with generalized estimating�…
Context
Thyroid diseases are inconsistently reported to increase risk for pregnancy complications.
Objective
The objective of this study was to study pregnancy complications associated with common and uncommon thyroid diseases.
Design, Setting, and Participants
We analyzed singleton pregnancies (N = 223 512) from a retrospective US cohort, the Consortium on Safe Labor (2002–2008). Thyroid diseases and outcomes were derived from electronic medical records. Multivariable logistic regression with generalized estimating equations estimated adjusted odds ratios (ORs) with 99% confidence intervals (99% CI).
Main Outcome Measures
Hypertensive diseases, diabetes, preterm birth, cesarean sections, inductions, and intensive care unit (ICU) admissions were analyzed.
Results
Primary hypothyroidism was associated with increased odds of preeclampsia (OR = 1.47, 99% CI = 1.20–1.81), superimposed preeclampsia (OR = 2.25, 99% CI = 1.53–3.29), gestational diabetes (OR = 1.57, 99% CI = 1.33–1.86), preterm birth (OR = 1.34, 99% CI = 1.17–1.53), induction (OR = 1.15, 99% CI = 1.04–1.28), cesarean section (prelabor, OR = 1.31, 99% CI = 1.11–1.54; after spontaneous labor OR = 1.38, 99% CI = 1.14–1.66), and ICU admission (OR = 2.08, 99% CI = 1.04–4.15). Iatrogenic hypothyroidism was associated with increased odds of placental abruption (OR = 2.89, 99% CI = 1.14–7.36), breech presentation (OR = 2.09, 99% CI = 1.07–4.07), and cesarean section after spontaneous labor (OR = 2.05, 99% CI = 1.01–4.16). Hyperthyroidism was associated with increased odds of preeclampsia (OR = 1.78, 99% CI = 1.08–2.94), superimposed preeclampsia (OR = 3.64, 99% CI = 1.82–7.29), preterm birth (OR = 1.81, 99% CI = 1.32–2.49), induction (OR = 1.40, 99% CI = 1.06–1.86), and ICU admission (OR = 3.70, 99% CI = 1.16–11.80).
Conclusions
Thyroid diseases were associated with obstetrical, labor, and delivery complications. Although we lacked information on treatment during pregnancy, these nationwide data suggest either that there is a need for better thyroid disease management during pregnancy or that there may be an intrinsic aspect of thyroid disease that causes poor pregnancy outcomes.
Oxford University Press