Biosynthesis, remodeling and turnover of mitochondrial cardiolipin
M Schlame, ML Greenberg�- …�et Biophysica Acta (BBA)-Molecular and Cell�…, 2017 - Elsevier
M Schlame, ML Greenberg
Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 2017•ElsevierAmong mitochondrial lipids, cardiolipin occupies a unique place. It is the only phospholipid
that is specific to mitochondria and although it is merely a minor component, accounting for
10-20% of the total phospholipid content, cardiolipin plays an important role in the molecular
organization, and thus the function of the cristae. This review covers the formation of
cardiolipin, a phospholipid dimer containing two phosphatidyl residues, and its assembly
into mitochondrial membranes. While a large body of literature exists on this topic, the�…
that is specific to mitochondria and although it is merely a minor component, accounting for
10-20% of the total phospholipid content, cardiolipin plays an important role in the molecular
organization, and thus the function of the cristae. This review covers the formation of
cardiolipin, a phospholipid dimer containing two phosphatidyl residues, and its assembly
into mitochondrial membranes. While a large body of literature exists on this topic, the�…
Abstract
Among mitochondrial lipids, cardiolipin occupies a unique place. It is the only phospholipid that is specific to mitochondria and although it is merely a minor component, accounting for 10-20% of the total phospholipid content, cardiolipin plays an important role in the molecular organization, and thus the function of the cristae. This review covers the formation of cardiolipin, a phospholipid dimer containing two phosphatidyl residues, and its assembly into mitochondrial membranes. While a large body of literature exists on this topic, the review focuses on papers that appeared in the past three years. This article is part of a Special Issue entitled: Lipids of Mitochondria edited by Guenther Daum.
Elsevier