Effect of noxious tail pinch on the discharge rate of mesocortical and mesolimbic dopamine neurons: selective activation of the mesocortical system
J Mantz, AM Thierry, J Glowinski�- Brain research, 1989 - Elsevier
J Mantz, AM Thierry, J Glowinski
Brain research, 1989•ElsevierThe effects of noxious tail pinch on the activity of mesocortical and mesolimbic dopamine
(DA) neurons located in the ventromedial mesencephalic tegmentum were analyzed in
ketamine-anesthetized rats. The great majority of mesocortical DA neurons responded to tail
pinch, either by an excitation (65%), or by an inhibition (25%). In contrast, most DA neurons
projecting either to the nucleus accumbens or the septum remained unaffected. These
results demonstrate that noxious tail pinch selectivity influences the firing rate of�…
(DA) neurons located in the ventromedial mesencephalic tegmentum were analyzed in
ketamine-anesthetized rats. The great majority of mesocortical DA neurons responded to tail
pinch, either by an excitation (65%), or by an inhibition (25%). In contrast, most DA neurons
projecting either to the nucleus accumbens or the septum remained unaffected. These
results demonstrate that noxious tail pinch selectivity influences the firing rate of�…
Abstract
The effects of noxious tail pinch on the activity of mesocortical and mesolimbic dopamine (DA) neurons located in the ventromedial mesencephalic tegmentum were analyzed in ketamine-anesthetized rats. The great majority of mesocortical DA neurons responded to tail pinch, either by an excitation (65%), or by an inhibition (25%). In contrast, most DA neurons projecting either to the nucleus accumbens or the septum remained unaffected. These results demonstrate that noxious tail pinch selectivity influences the firing rate of mesocortical DA neurons.
Elsevier