DNA-based catalytic enantioselective intermolecular oxa-Michael addition reactions
RP Megens, G Roelfes�- Chemical communications, 2012 - pubs.rsc.org
RP Megens, G Roelfes
Chemical communications, 2012•pubs.rsc.orgUsing the DNA-based catalysis concept, a novel Cu (II) catalyzed enantioselective oxa-
Michael addition of alcohols to enones is reported. Enantioselectivities of up to 86% were
obtained. The presence of water is important for the reactivity, possibly by reverting
unwanted side reactions such as 1, 2-additions.
Michael addition of alcohols to enones is reported. Enantioselectivities of up to 86% were
obtained. The presence of water is important for the reactivity, possibly by reverting
unwanted side reactions such as 1, 2-additions.
Using the DNA-based catalysis concept, a novel Cu(II) catalyzed enantioselective oxa-Michael addition of alcohols to enones is reported. Enantioselectivities of up to 86% were obtained. The presence of water is important for the reactivity, possibly by reverting unwanted side reactions such as 1,2-additions.
The Royal Society of Chemistry