Sexual dimorphism in the adolescent brain: role of testosterone and androgen receptor in global and local volumes of grey and white matter
T Paus, I Nawaz-Khan, G Leonard, M Perron…�- Hormones and�…, 2010 - Elsevier
Here we examined sex differences in the volumes of grey and white matter, and in grey-
matter “density,” in a group of typically developing adolescents participating in the Saguenay
Youth Study (n= 419; 12–18 years). In male adolescents, we also investigated the role of a
functional polymorphism in androgen-receptor gene (AR) in moderating the effect of
testosterone on volumes of grey and white matter and grey-matter density. Overall, both
absolute and relative volumes of white matter were larger in male vs. females adolescents�…
matter “density,” in a group of typically developing adolescents participating in the Saguenay
Youth Study (n= 419; 12–18 years). In male adolescents, we also investigated the role of a
functional polymorphism in androgen-receptor gene (AR) in moderating the effect of
testosterone on volumes of grey and white matter and grey-matter density. Overall, both
absolute and relative volumes of white matter were larger in male vs. females adolescents�…