[HTML][HTML] CXC chemokine receptor 3 promotes steatohepatitis in mice through mediating inflammatory cytokines, macrophages and autophagy
Background & Aims CXC chemokine receptor 3 (CXCR3) is involved in virus-related chronic
liver inflammation. However, the role of CXCR3 in non-alcoholic steatohepatitis (NASH)
remains unclear. We aimed to investigate the role of CXCR3 in NASH. Methods Human liver
tissues were obtained from 24 non-alcoholic fatty liver disease (NAFLD) patients and 20
control subjects. CXCR3 knockout (CXCR3−/−), obese db/db mice and their wild-type (WT)
littermates were used in both methionine-and-choline-deficient (MCD) diet and high-fat high�…
liver inflammation. However, the role of CXCR3 in non-alcoholic steatohepatitis (NASH)
remains unclear. We aimed to investigate the role of CXCR3 in NASH. Methods Human liver
tissues were obtained from 24 non-alcoholic fatty liver disease (NAFLD) patients and 20
control subjects. CXCR3 knockout (CXCR3−/−), obese db/db mice and their wild-type (WT)
littermates were used in both methionine-and-choline-deficient (MCD) diet and high-fat high�…