C-reactive protein, interleukin-6, soluble tumor necrosis factor α receptor 2 and incident clinical depression
PO Chocano-Bedoya, F Mirzaei, EJ O'Reilly…�- Journal of affective�…, 2014 - Elsevier
Journal of affective disorders, 2014•Elsevier
Background Despite an extensive literature on the role of inflammation and depression, few
studies have evaluated the association between inflammatory biomarkers and depression in
a prospective manner, and results are inconclusive. Methods We conducted a prospective
analysis of blood levels of CRP, IL-6 and TNFα-R2 in 4756 women participating in the
Nurses׳ Health Study who donated blood in 1990 and were depression-free up to 1996.
Participants were followed between 1996 and 2008 for reports of clinical diagnosis�…
studies have evaluated the association between inflammatory biomarkers and depression in
a prospective manner, and results are inconclusive. Methods We conducted a prospective
analysis of blood levels of CRP, IL-6 and TNFα-R2 in 4756 women participating in the
Nurses׳ Health Study who donated blood in 1990 and were depression-free up to 1996.
Participants were followed between 1996 and 2008 for reports of clinical diagnosis�…
Background
Despite an extensive literature on the role of inflammation and depression, few studies have evaluated the association between inflammatory biomarkers and depression in a prospective manner, and results are inconclusive.
Methods
We conducted a prospective analysis of blood levels of CRP, IL-6 and TNFα-R2 in 4756 women participating in the Nurses׳ Health Study who donated blood in 1990 and were depression-free up to 1996. Participants were followed between 1996 and 2008 for reports of clinical diagnosis depression or antidepressant use. Additionally, we conducted cross-sectional analyses for CRP, IL-6 and TNFα-R2 and antidepressant use at time of blood draw.
Results
After adjustment for body mass index, menopause status, use of anti-inflammatory drugs and other covariates, no significant associations between CRP, IL-6 and TNFα-R2 and incident depression were observed after a follow-up of 6−18 years. However, menopause status appears to modify the association between IL-6 and depression risk. In cross-sectional analyses, TNFα-R2 was associated with antidepressant use (OR=1.96, 95% CI=1.23−3.13, P-trend=0.001), but no significant associations were found for CRP and IL-6.
Limitations
Depression diagnosis was first assessed in 1996, 6 years after blood draw. However the biomarkers have high within-person correlations with measurements 4 years apart.
Conclusions
Blood levels of CRP, IL-6 and TNFα-R2 were not associated with incident depression over a follow-up of 6–18 years. In cross-sectional analyses, antidepressant use may be associated with higher levels of TNFα-R2 but no associations with depression or antidepressant use were observed in the prospective analysis.
Elsevier