Immunohistochemical over-expression of HER2 does not always match with gene amplification in invasive bladder cancer
T Franceschini, E Capizzi, F Massari…�- …�-Research and Practice, 2020 - Elsevier
Background HER2 is a potential target of therapy in urothelial cancer (UC). Pathological
case stratification according to HER2 gene amplification or HER2 protein overexpression
was critical for patients' selection in previous unsuccessful clinical trial with HER2 targeting
agents. Study design We evaluated the HER2 overexpression by immunohistochemistry
(IHC) together with the amplification of the HER2 gene with chromogenic (CISH) and
fluorescent (FISH) in situ hybridization in a cohort of 61 patients covering the whole�…
case stratification according to HER2 gene amplification or HER2 protein overexpression
was critical for patients' selection in previous unsuccessful clinical trial with HER2 targeting
agents. Study design We evaluated the HER2 overexpression by immunohistochemistry
(IHC) together with the amplification of the HER2 gene with chromogenic (CISH) and
fluorescent (FISH) in situ hybridization in a cohort of 61 patients covering the whole�…