Context: Although response to therapy assessment is a validated tool for dynamic risk
stratification in patients with differentiated thyroid cancer (DTC) treated with total
thyroidectomy (TT) and radioactive iodine therapy (RAI), it has not been well studied in
patients treated with lobectomy or TT without RAI. Because these responses to therapy
definitions are heavily dependent on serum thyroglobulin (Tg) levels, modifications of the
original definitions were needed to appropriately classify patients treated without RAI�…

Background: Increased incidence of small differentiated thyroid cancer (DTC) has
emphasized the need for risk stratification and individualized disease management for these
low risk DTCs. The aim of this study was to validate a new dynamic risk stratification (DRS)
system for the prediction of structural recurrent/persistent disease in patients with DTC
treated without radioactive iodine (RAI) remnant ablation therapy. Methods: This historical
cohort study included 357 patients with DTC treated with lobectomy or total thyroidectomy�…