Synthesis of a potent and selective inhibitor of p90 Rsk
DJ Maloney, SM Hecht�- Organic letters, 2005 - ACS Publications
DJ Maloney, SM Hecht
Organic letters, 2005•ACS PublicationsThe synthesis of the naturally occurring kaempferol glycoside SL0101 has been
accomplished, as has its biochemical evaluation. SL0101 exhibits selective and potent p90
Rsk inhibitory activity at nanomolar concentrations without inhibiting the function of upstream
kinases such as MEK, Raf, or PKC. The synthesis verified the structural assignment of the
natural product and has provided access to material sufficient for detailed biological
evaluation.
accomplished, as has its biochemical evaluation. SL0101 exhibits selective and potent p90
Rsk inhibitory activity at nanomolar concentrations without inhibiting the function of upstream
kinases such as MEK, Raf, or PKC. The synthesis verified the structural assignment of the
natural product and has provided access to material sufficient for detailed biological
evaluation.
The synthesis of the naturally occurring kaempferol glycoside SL0101 has been accomplished, as has its biochemical evaluation. SL0101 exhibits selective and potent p90 Rsk inhibitory activity at nanomolar concentrations without inhibiting the function of upstream kinases such as MEK, Raf, or PKC. The synthesis verified the structural assignment of the natural product and has provided access to material sufficient for detailed biological evaluation.
ACS Publications