Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo–pituitary–adrenocortical responsiveness
JP Herman, H Figueiredo, NK Mueller…�- Frontiers in�…, 2003 - Elsevier
Appropriate regulatory control of the hypothalamo–pituitary–adrenocortical stress axis is
essential to health and survival. The following review documents the principle extrinsic and
intrinsic mechanisms responsible for regulating stress-responsive CRH neurons of the
hypothalamic paraventricular nucleus, which summate excitatory and inhibitory inputs into a
net secretory signal at the pituitary gland. Regions that directly innervate these neurons are
primed to relay sensory information, including visceral afferents, nociceptors and�…
essential to health and survival. The following review documents the principle extrinsic and
intrinsic mechanisms responsible for regulating stress-responsive CRH neurons of the
hypothalamic paraventricular nucleus, which summate excitatory and inhibitory inputs into a
net secretory signal at the pituitary gland. Regions that directly innervate these neurons are
primed to relay sensory information, including visceral afferents, nociceptors and�…