Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism
BACKGROUND: In the neurodevelopmental disorder autism, several neuroimmune
abnormalities have been reported. However, it is unknown whether microglial somal volume
or density are altered in the cortex and whether any alteration is associated with age or other
potential covariates. METHODS: Microglia in sections from the dorsolateral prefrontal cortex
of nonmacrencephalic male cases with autism (n= 13) and control cases (n= 9) were
visualized via ionized calcium binding adapter molecule 1 immunohistochemistry. In�…
abnormalities have been reported. However, it is unknown whether microglial somal volume
or density are altered in the cortex and whether any alteration is associated with age or other
potential covariates. METHODS: Microglia in sections from the dorsolateral prefrontal cortex
of nonmacrencephalic male cases with autism (n= 13) and control cases (n= 9) were
visualized via ionized calcium binding adapter molecule 1 immunohistochemistry. In�…