Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus
HS Oliff, NC Berchtold, P Isackson…�- Molecular Brain Research, 1998 - Elsevier
Previous results from our laboratory indicate that two nights of voluntary wheel running
upregulates brain-derived neurotrophic factor (BDNF) mRNA expression in the
hippocampus. In order to investigate the time-course of the BDNF response and to examine
how physical activity preferentially activates particular transcriptional pathways, the effects of
6 and 12 h of voluntary wheel running on BDNF and exons I–IV mRNA expression were
investigated in rats. Hippocampal full-length BDNF mRNA expression was rapidly�…
upregulates brain-derived neurotrophic factor (BDNF) mRNA expression in the
hippocampus. In order to investigate the time-course of the BDNF response and to examine
how physical activity preferentially activates particular transcriptional pathways, the effects of
6 and 12 h of voluntary wheel running on BDNF and exons I–IV mRNA expression were
investigated in rats. Hippocampal full-length BDNF mRNA expression was rapidly�…