[HTML][HTML] Hepatic cholesterol crystals and crown-like structures distinguish NASH from simple steatosis [S]
GN Ioannou, WG Haigh, D Thorning, C Savard�- Journal of lipid research, 2013 - ASBMB
We sought to determine whether hepatic cholesterol crystals are present in patients or mice
with nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NASH), and whether their
presence or distribution correlates with the presence of NASH as compared with simple
steatosis. We identified, by filipin staining, free cholesterol within hepatocyte lipid droplets in
patients with NASH and in C57BL/6J mice that developed NASH following a high-fat high-
cholesterol diet. Under polarized light these lipid droplets exhibited strong birefringence�…
with nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NASH), and whether their
presence or distribution correlates with the presence of NASH as compared with simple
steatosis. We identified, by filipin staining, free cholesterol within hepatocyte lipid droplets in
patients with NASH and in C57BL/6J mice that developed NASH following a high-fat high-
cholesterol diet. Under polarized light these lipid droplets exhibited strong birefringence�…